Repeating developmental expression of G-Hox 7, a novel homeobox-containing gene in the chicken.
Repeating developmental expression of G-Hox 7, a novel homeobox-containing gene in the chicken.
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DOI：
10.1016/0012-1606(91)90345-4
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发表时间：
1991-11
影响因子：
2.7
通讯作者：
H. Suzuki;B. Padanilam;E. Vitale;F. Ramirez;M. Solursh
中科院分区：
文献类型：
--
作者：
H. Suzuki;B. Padanilam;E. Vitale;F. Ramirez;M. Solursh
本文描述了一个新的含有鸡同源盒的基因G-Hox 7的分离和鉴定，该基因与果蝇msh相关。推导的氨基酸序列显示大于96%的同源性，其他脊椎动物的类基因的同源结构域。与其他物种相比，G-Hox 7蛋白的氨基端和羧基端在遗传学上有很大差异。原位杂交研究表明，G-Hox 7在鸡的发育过程中早期广泛表达。这包括其在原始条纹和经历外包的胚外细胞中的表达，以及其沿着神经轴（包括前脑）的表达。在神经嵴、神经嵴衍生的面部和鳃结构、耳囊、肢体和心脏瓣膜中也观察到表达。这种广泛的和经常性的表达的转录本表明，该基因可能在多个网站在新的发展途径的启动过程中发挥重要作用。
Here we describe the isolation and characterization of a new chicken homeobox-containing gene, G-Hox 7, which is related toDrosophila msh. The deduced amino acid sequence of the cDNA shows greater than 96% homology to the homeo domain of other vertebratemsh-like genes. As for other species, the amino and carboxy termini of the protein are, however, greatly divergent when compared phylogenetically.In situhybridization studies revealed the early and widespread expression of G-Hox 7 during chick development. This includes its expression in the primitive streak and extraembryonic cells undergoing epiboly, and its expression along the neural axis, including the forebrain. Expression was also observed in the neural crest, neural crest-derived facial and branchial structures, the otocyst, limb, and heart valves. This widespread and recurrent expression of the transcript suggests that the gene may play an essential role at multiple sites during the initiation of new developmental pathways.