High-density lipoproteins and the immune system.
High-density lipoproteins and the immune system.
复制标题
DOI：
10.1155/2013/684903
复制
发表时间：
2013
影响因子：
5.3
通讯作者：
Kaji H
中科院分区：
文献类型：
--
作者：
Kaji H
高密度脂蛋白在血管扩张和减少低密度脂蛋白氧化、炎症、细胞凋亡、血栓形成和感染等方面发挥着重要作用；然而，在某些情况下，高密度脂蛋白在这些作用中的作用较弱。本文重点介绍了高密度脂蛋白及其抗炎行为，以及高密度脂蛋白与先天免疫系统和获得性免疫系统成分相互作用的机制。全基因组关联研究和蛋白质组学研究已经阐明了参与高密度脂蛋白和免疫系统相互作用的重要分子。对这些机制的了解有望有助于预防和治疗由代谢综合征、动脉粥样硬化或各种自身免疫性疾病引起的慢性炎症。
High-density lipoprotein (HDL) plays a major role in vasodilation and in the reduction of low-density lipoprotein (LDL) oxidation, inflammation, apoptosis, thrombosis, and infection; however, HDL is now less functional in these roles under certain conditions. This paper focuses on HDL, its anti-inflammation behavior, and the mechanisms by which HDL interacts with components of the innate and adaptive immune systems. Genome-wide association studies (GWAS) and proteomic studies have elucidated important molecules involved in the interaction between HDL and the immune system. An understanding of these mechanisms is expected to be useful for the prevention and treatment of chronic inflammation due to metabolic syndrome, atherosclerosis, or various autoimmune diseases.