CIGARETTE-SMOKING AND PANCREAS CANCER - A CASE-CONTROL STUDY BASED ON DIRECT INTERVIEWS
CIGARETTE-SMOKING AND PANCREAS CANCER - A CASE-CONTROL STUDY BASED ON DIRECT INTERVIEWS
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DOI：
10.1093/jnci/86.20.1510
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发表时间：
1994-10-19
影响因子：
10.3
通讯作者：
POTTERN, LM
中科院分区：
文献类型：
--
作者：
SILVERMAN, DT;DUNN, JA;POTTERN, LM
背景资料：吸烟是胰腺癌最常报告的危险因素，但许多胰腺癌研究中的剂量-反应关系很弱。由于胰腺癌的预后不良，许多病例对照研究主要基于对代理受访者的采访，这些受访者报告的详细吸烟习惯的可靠信息比原始受试者少。目的：我们的目的是评估吸烟作为胰腺癌的危险因素的基础上获得的数据仅从直接采访，并估计戒烟的影响，从非过滤嘴香烟转换为过滤嘴香烟的风险。我们的目的也是评估吸烟对解释美国黑人胰腺癌发病率高于白色美国人的贡献。方法：1986-1989年在佐治亚州亚特兰大市进行了一项以人群为基础的胰腺癌病例对照研究，密歇根州底特律，以及新泽西的10个县。直接访谈成功完成了526例病例患者和2153例对照受试者，年龄在30-79岁之间，使其成为迄今为止仅基于直接访谈的最大的基于人群的胰腺癌病例对照研究。结果：与不吸烟者相比，吸烟者患胰腺癌的风险显著增加70%。随着吸烟时间的增加，风险呈明显的正趋势（P
Background: Cigarette smoking is the most consistently reported risk factor for pancreas cancer, yet the dose-response relationship in many pancreas cancer studies is weak. Because of the poor prognosis for pancreas cancer, many case-control studies have been based largely on interviews with proxy respondents, who are known to report less reliable information on detailed smoking habits than original subjects. Purpose: Our purpose was to evaluate cigarette smoking as a risk factor for pancreas cancer based on data obtained only from direct interviews and to estimate the effects of quitting smoking and of switching from nonfiltered to filtered cigarettes on risk. Our objective also was to estimate the contribution of cigarette smoking toward explaining the higher pancreas cancer incidence experienced by black Americans compared with white Americans. Methods: A population-based, case-control study of pancreas cancer was conducted during 1986-1989 in Atlanta, Ga., Detroit, Mich., and 10 counties in New Jersey. Direct interviews were successfully completed with 526 case patients and 2153 control subjects aged 30-79 years, making this the largest population-based, case-control study of pancreas cancer to date based only on direct interviews. Results: Cigarette smokers had a significant, 70% increased risk of pancreas cancer compared with the risk in nonsmokers. A significant, positive trend in risk with increasing duration smoked was apparent (P