Nonsurgical outpatient therapies for the management of female stress urinary incontinence: long-term effectiveness and durability.
Nonsurgical outpatient therapies for the management of female stress urinary incontinence: long-term effectiveness and durability.
复制标题
女性压力尿失禁的管理非外科门诊疗法：长期有效性和耐用性。
DOI：
10.1155/2011/176498
复制
发表时间：
2011
影响因子：
1.4
通讯作者：
Davila GW
中科院分区：
文献类型：
--
作者：
Davila GW
Objective.通过文献回顾，评价保守和微创门诊治疗女性压力性尿失禁（SUI）的长期有效性和安全性。 方法.在PubMed中检索关于SUI女性患者的微创治疗、盆底康复或药物治疗至少随访12个月的前瞻性临床试验报告。对每份报告的长期有效性和安全性进行了检查。 结果纳入了32份临床试验报告。骨盆底康复的前瞻性长期研究有限，但表明至少12个月的治疗依从性显着改善。度洛沙坦初始耐受性差导致大量停药。大多数接受经尿道射频胶原变性或尿道填充剂的患者报告了显着的长期改善，通常良好的耐受性和安全性。 结论.保守治疗是女性SUI的适当初始方法，但如果治疗失败，射频胶原变性或膨胀剂可能是一个有吸引力的中间管理步骤或替代手术。
Objective. To evaluate long-term effectiveness and safety of conservative and minimally invasive outpatient treatments for female stress urinary incontinence (SUI) through a review of the literature. Methods. PubMed was searched for reports on prospective clinical trials with at least 12-month follow-up of minimally invasive treatments, pelvic floor rehabilitation, or pharmacotherapy in women with SUI. Each report was examined for long-term rates of effectiveness and safety. Results. Thirty-two clinical trial reports were included. Prospective long-term studies of pelvic floor rehabilitation were limited but indicated significant improvements with treatment adherence for at least 12 months. Poor initial tolerability with duloxetine resulted in substantial discontinuation. Most patients receiving transurethral radiofrequency collagen denaturation or urethral bulking agents reported significant long-term improvements, generally good tolerability, and safety. Conclusions. Conservative therapy is an appropriate initial approach for female SUI, but if therapy fails, radiofrequency collagen denaturation or bulking agents may be an attractive intermediate management step or alternative to surgery.