Prevalence of CD99 protein expression in pancreatic endocrine tumours (PETs)
Prevalence of CD99 protein expression in pancreatic endocrine tumours (PETs)
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DOI：
10.1111/j.1365-2559.2004.01967.x
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发表时间：
2004-10-01
期刊：
影响因子：
6.4
通讯作者：
Fukayama, M
中科院分区：
文献类型：
--
作者：
Goto, A;Niki, T;Fukayama, M
目的：确定胰腺内分泌肿瘤（PET）中CD99表达的流行率。我们评估了CD99的表达，并分析了Ki67标记免疫组化PETs.Methods和结果：38 PETs从33例进行了分析。无论细胞类型如何，在正常胰岛中始终观察到CD 99免疫反应性。包含超过30%的CD99+细胞的肿瘤被定义为对CD99呈阳性免疫反应。在检查的38例PET中的20例中观察到CD99表达，但在其他组织学亚型的任何胰腺肿瘤中均未观察到CD99表达（10例导管腺癌、5例导管内乳头状粘液性肿瘤和2例腺泡细胞肿瘤）。CD99表达缺失与PET预后不良的标志物相关，包括大体局部浸润、淋巴结或其他器官转移、淋巴管或血管浸润和神经内分泌癌（NEC）。因此，CD99的表达可能有一个效率相媲美的高Ki67标记指数（5%或以上）的persistication.Conclusions：CD99的表达经常和专门观察到的PET，和损失的CD99表达PET被发现与不祥的预后指标。
Aims: To determine the prevalence of CD99 expression in pancreatic endocrine tumours (PETs). We evaluated CD99 expression and analysed Ki67 labelling by immunohistochemistry in PETs.Methods and results: Thirty-eight PETs from 33 patients were analysed. CD99 immunoreactivity was consistently observed in normal islets of the pancreas, regardless of the cell type. Tumours comprising more than 30% CD99+ cells were defined as positively immunoreactive for CD99. CD99 expression was observed in 20 of the 38 PETs examined, but not in any of the pancreatic tumours of other histological subtypes (10 ductal adenocarcinomas, five intraductal papillary-mucinous tumours, and two acinar cell tumours). Loss of CD99 expression was related to markers of worse prognosis for PET, including gross local invasion, metastasis to the lymph nodes or other organs, lymphatic or blood vessel invasion, and neuroendocrine carcinoma (NEC). Thus, CD99 expression may have an efficiency comparable to that of high Ki67 labelling index (5% or more) for prognostication.Conclusions: CD99 expression was observed frequently and exclusively in PETs, and loss of CD99 expression in PETs was found to be associated with ominous prognostic indicators.