HIGH-DOSE DOXORUBICIN PLUS CISPLATIN IN THE TREATMENT OF UNRESECTABLE MESOTHELIOMAS - REPORT OF 4 CASES
HIGH-DOSE DOXORUBICIN PLUS CISPLATIN IN THE TREATMENT OF UNRESECTABLE MESOTHELIOMAS - REPORT OF 4 CASES
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DOI：
10.1016/0169-5002(94)90545-2
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发表时间：
1994-09-01
期刊：
影响因子：
5.3
通讯作者：
EVANS, WK
中科院分区：
文献类型：
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作者：
STEWART, DJ;GERTLER, SZ;EVANS, WK
只有很小一部分间皮瘤患者可以通过手术治愈。放疗和标准化疗通常被认为只有有限的用处。在本文中，我们报告了4例不可切除的间皮瘤患者，顺铂105- 120mg /m(2)加阿霉素90mg /m(2)联合治疗。毒性很大，所有4例患者均出现中性粒细胞减少性败血症和其他3级毒性，但无治疗相关死亡。有2例患者完全缓解（1例持续4年），1例部分缓解，1例病情稳定，症状明显改善。这种组合是有毒的，但疗效的轶事证据表明，它可能比低剂量的化疗更有效。对于不能切除的间皮瘤患者，它值得进一步的研究。
Only a very small proportion of all patients with mesotheliomas can be cured surgically. Both radiotherapy and standard chemotherapy are generally considered to be of only limited usefulness. In this paper, we report four patients with unresectable mesotheliomas treated with the combination of cisplatin 105-120 mg/m(2) plus doxorubicin 90 mg/m(2). Toxicity was substantial, in that all four patients developed neutropenic sepsis and other grade 3 toxicity, but there were no treatment-related deaths. There were two,patients with complete remissions (one persisting at >4 years), one partial remission, and one stable disease with marked symptomatic improvement. This combination is toxic, but the anecdotal evidence of efficacy is suggestive that it may possibly be more active than lower doses of chemotherapy. It warrants further study in good performance status patients with unresectable mesotheliomas.