Serum carboxy-terminal telopeptide of type I collagen levels are associated with carotid atherosclerosis in patients with cardiovascular risk factors
Serum carboxy-terminal telopeptide of type I collagen levels are associated with carotid atherosclerosis in patients with cardiovascular risk factors
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DOI：
10.1507/endocrj.ej15-0589
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发表时间：
2016-04-20
影响因子：
2
通讯作者：
Abe, Masahiro
中科院分区：
文献类型：
--
作者：
Kondo, Takeshi;Endo, Itsuro;Abe, Masahiro
I型胶原羧基末端肽（ICTP）是通过基质金属蛋白酶（MMP）依赖的I型胶原消化产生的，并已被广泛用作骨转换的生物标志物。动脉粥样硬化病变富含I型胶原和MMP-产生的巨噬细胞，这一事实导致了血清ICTP浓度可能作为动脉粥样硬化的非侵入性临床生物标志物的假设。因此，在有动脉粥样硬化危险因素的患者中，评价了血清ICTP浓度与颈动脉最大内膜中层厚度（IMT）（全身动脉粥样硬化的替代指标）或臂踝脉搏波速度（baPWV）的相关性。共招募了52名男性和65名女性（平均年龄：62.8岁）患者，这些患者没有已知影响血清ICTP浓度的肾衰竭、恶性肿瘤或骨病。最大IMT>= 1.1 mm的患者血清ICTP浓度显著高于最大IMT的患者
Carboxy-terminal telopeptide of type I collagen (ICTP) is generated through matrix metalloproteinase (MMP)-dependent type I collagen digestion, and has been widely utilized as a biomarker for bone turnover. The fact that atherosclerotic lesions are rich in both type I collagen and MMP-producing macrophages led to the hypothesis that serum ICTP concentrations may serve as a non-invasive clinical biomarker for atherosclerosis. Therefore, the association of serum ICTP concentrations with the maximum intima-media thickness (IMT) of carotid arteries, a surrogate index of systemic atherosclerosis, or brachial-ankle pulse wave velocity (baPWV) in patients with atherosclerotic risk factors was evaluated. A total of 52 male and 65 female (mean age: 62.8 yrs) patients without renal failure, malignancies or bone diseases known to affect serum ICTP concentrations were recruited. Patients with max IMTs >= 1.1 mm showed significantly higher serum ICTP concentrations compared with patients with max IMTs