Age at menopause onset and risk of cardiovascular disease around the world
Age at menopause onset and risk of cardiovascular disease around the world
复制标题
DOI：
10.1016/j.maturitas.2020.06.007
复制
发表时间：
2020-11-01
期刊：
影响因子：
4.9
通讯作者：
El Khoudary, Samar R.
中科院分区：
文献类型：
--
作者：
El Khoudary, Samar R.
更年期提前与心血管疾病的风险增加有关。更年期的开始和心血管疾病的风险因地理区域、种族/民族和社会经济地位而异。因此，可以推测这些因素可能会影响更年期开始与心血管疾病风险之间的关联。这篇叙述性综述采用全球方法，重点关注地理、种族/民族和社会经济因素如何影响更年期的开始，主要是自然更年期，以及它可能与心血管疾病风险的关联。还总结了遗传因素对更年期开始变异的贡献。文献中存在明显的空白。一些荟萃分析通过结合广泛地理区域的不同种族/民族背景和社会经济地位的大量人群，评估了更年期的开始是否与心血管疾病风险相关的问题。这些分析都没有充分评估这些因素如何改变更年期发作和心血管疾病风险的关联。测试这样的问题需要对不同地理位置的大量不同种族/民族背景的女性进行研究，并详细记录她们的社会经济地位、临床和环境因素。越来越多的证据支持更年期开始年龄作为整体健康的标志，呼吁全世界努力在临床和研究领域实施标准化方法来定义更年期年龄。
Earlier menopause onset has been linked to a greater risk of cardiovascular disease. Both menopause onset and cardiovascular disease risk vary by geographical region, race/ethnicity and socioeconomic status. As such, it is plausible to hypothesize that these factors may influence the association of menopause onset and cardiovascular disease risk. Taking a global approach, this narrative review focuses on how geographic, racial/ethnic and socioeconomic factors might influence menopause onset, mainly natural menopause, and possibly its association with cardiovascular disease risk. The contribution of genetic factors to menopause onset variation is also summarized. A clear gap in the literature has been identified. Several meta-analyses have assessed the question of whether menopause onset is related to cardiovascular disease risk by combining large populations of diverse racial/ethnic backgrounds and socioeconomic status across wide geographical regions. None of these analyses adequately assessed how these factors might modify the association of menopause onset and cardiovascular disease risk. Testing such a question requires the study of a large group of women of diverse racial/ethnic backgrounds across different geographical locations with good documentation of their socioeconomic status, clinical and environmental factors. The increasing evidence supporting age at menopause onset as a marker of overall health calls for worldwide efforts to implement a standardized approach to define age at menopause in both the clinical and the research fields.