RBE OF A THERMAL-NEUTRON BEAM AND THE B-10(N,ALPHA)LI-7 REACTION ON CULTURED B-16 MELANOMA-CELLS
RBE OF A THERMAL-NEUTRON BEAM AND THE B-10(N,ALPHA)LI-7 REACTION ON CULTURED B-16 MELANOMA-CELLS
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DOI：
10.1080/09553008714550601
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发表时间：
1987-01-01
影响因子：
2.6
通讯作者：
MISHIMA, Y
中科院分区：
文献类型：
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作者：
FUKUDA, H;KOBAYASHI, T;MISHIMA, Y
热中子束与10B（n, .alpha.）的RBE在培养的B-16黑色素瘤细胞中测定7Li反应。京都大学研究堆（KUR）作为热中子源，具有极低的γ射线和快中子污染。在10b -硼酸存在或不存在的情况下，用光束照射细胞。中子捕获反应对细胞的吸收剂量用Kitao（1975）的方法计算。两种情况下的生存曲线均无肩膊，存在或不存在5 .mu时的D0值为0.506 0.604 Gy。g 10B/ml-medium。10B的D0值（n, .alpha.）假设辐射各组分为可加性，估计7Li反应为0.466 Gy。KUR热中子束和10B（n, .alpha。）7Li反应相对于60Co伽马射线在0.1存活分数下分别为4.62和6.01。利用这些结果，我们计算了10b化合物的吸收剂量，并估计了10b化合物在培养细胞中的特定积累，我们之前报道过但没有量化（Nakanishi et al. 1980, Ichihashi et al. 1982）。
The RBE of a thermal neutron beam and the 10B(n, .alpha.)7Li reaction were determined in cultured B-16 melanoma cells. The Kyoto University Research Reactor (KUR) was used as a thermal neutron source which had a very low contamination of gamma-rays and fast neutrons. The cells were irradiated with the beam in the presence or absence of 10B-boric acid. The absorbed dose from the neutron capture reaction to the cells was calculated by a method of Kitao (1975). Survival curves in both conditions had no shoulder, and D0 values were 0.506 0.604 Gy in the presence or absence of 5 .mu.g 10B/ml-medium, respectively. The D0 value of the 10B(n, .alpha.)7Li reaction was also estimated at 0.466 Gy, assuming each component of radiation was additive. The RBEs of the KUR thermal neutron beam and the 10B(n, .alpha.)7Li reaction relative to 60Co gamma-rays were estimated as 4.62 and 6.01 at 0.1 surviving fraction, respectively. Using these results, we calculated the absorbed dose from the 10B-compound and estimated the specific accumulation in the cultured cells of 10B-compounds which we have previously reported but not quantified (Nakanishi et al. 1980, Ichihashi et al. 1982).