APOLIPOPROTEIN-E, DEMENTIA, AND CORTICAL DEPOSITION OF BETA-AMYLOID PROTEIN
APOLIPOPROTEIN-E, DEMENTIA, AND CORTICAL DEPOSITION OF BETA-AMYLOID PROTEIN
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DOI：
10.1056/nejm199511093331902
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发表时间：
1995-11-09
影响因子：
158.5
通讯作者：
KONTULA, K
中科院分区：
文献类型：
--
作者：
POLVIKOSKI, T;SULKAVA, R;KONTULA, K
Background. The epsilon 4 allele of apolipoprotein E has been associated with an increased risk of late-onset Alzheimer's disease. In a cohort of elderly subjects we prospectively investigated the relation between the apolipoprotein E genotype, dementia, and the accumulation of beta-amyloid protein in the cerebral cortex.Methods. Autopsy involving neuropathological analysis and DNA analysis of frozen blood samples was performed in 92 of 271 persons who were at least 85 years of age, who had been living in Vantaa, Finland, on April 1, 1991, and who had died between that time and the end of 1993. All subjects had been tested for dementia, Apolipoprotein E genotyping was done with a solid-phase minisequencing technique. The percentage of the cortex occupied by methenamine silver-stained plaques was used as an estimate of the extent of beta-amyloid protein deposition.Results. The frequency of the epsilon 4 allele was significantly higher in the subjects with Alzheimer's disease than in the subjects without dementia (30 percent vs, 8 percent, P
