Upregulation of DEAD box helicase 5 and 17 are correlated with the progression and poor prognosis in gliomas
Upregulation of DEAD box helicase 5 and 17 are correlated with the progression and poor prognosis in gliomas
复制标题
DOI：
10.1016/j.prp.2020.152828
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Guanglong Huang
中科院分区：
文献类型：
--
作者：
Qisheng Luo;Tianshi Que;Hongcheng Luo;Haineng Huang;Rentong Hu;Kunxiang Luo;Chuanhua Zheng;Peng Yan;Guanglong Huang
Recent researches indicated Ddx5 and Ddx17 play crucial roles in tumorigenesis. However, the study of Ddx5.and Ddx17 in glioma remains a little. Our study investigated their expression in glioma and evaluated its as-.sociation with clinical factors and prognostic significance. The expression of Ddx5 and Ddx17 were both up-.regulated in glioma tissues compared to normal brain tissues, and a significant positive correlation between.Ddx5 and Ddx17 expression was identified by statistical analysis. Immunohistochemical staining verified the.expression of Ddx5 and Ddx17 in peritumoral zone was lower than that in core zone but higher than normal.brain tissues. Moreover, the increased expression of Ddx5 and Ddx17 was markedly correlated with WHO Grade.and histological type, and high Ddx5 and Ddx17 were found to be significantly associated with the worse overall.survival of glioma patients. In additional, higher expression of both Ddx5 and Ddx17 predicted shorter clinical.survival time for high-grade glioma patients with radiotherapy or with chemotherapy. In conclusion, over-.expressed Ddx5 and Ddx17 are involved in the clinical progression and poor prognosis of glioma patients,.suggesting that their upregulation can be used as a reliable clinical predictor for tumor diagnosis and to predict.survival in patients with glioma
