C-MYC AND C-MYB EXPRESSION IN ACUTE MYELOGENOUS LEUKEMIA
C-MYC AND C-MYB EXPRESSION IN ACUTE MYELOGENOUS LEUKEMIA
复制标题
DOI：
10.1016/0145-2126(92)90080-q
复制
发表时间：
1992-10-01
影响因子：
2.7
通讯作者：
PREISLER, H
中科院分区：
文献类型：
--
作者：
GOPAL, V;HULETTE, B;PREISLER, H
应用单克隆抗体和流式细胞术检测急性髓细胞白血病（AML）患者骨髓（BM）和外周血（PB）细胞中c-myc和c-myb的表达。两种基因的表达均与BM或PB中的原始细胞百分比无关，c-myc和c-myb表达之间也无相关性。在每种FAB类型的AML中发现了每种基因的广泛表达。与低比例表达c-myb的患者相比，高比例表达c-myb的白血病细胞的患者对缓解诱导治疗的反应较低。这种关联似乎反映了表达c-myb的细胞比例与白血病细胞对体内化疗杀伤作用的敏感性之间的反比关系。治疗结果与c-myc表达无关。
Monoclonal antibodies and flow cytometry were used to detect the expression of c-myc and c-myb in the bone marrow (BM) and peripheral blood (PB) cells of patients with acute myelogenous leukemia (AML). The expression of neither gene was correlated with the percent blast cells in the BM or PB nor was there a correlation between c-myc and c-myb expression. A wide range of expression of each gene was found within each FAB type of AML. Patients who had a high proportion of leukemia cells expressing c-myb were less likely to respond to remission induction therapy than patients in whom a low proportion of cells expressed c-myb. This association appears to reflect an inverse relationship between the proportion of cells expressing c-myb and the sensitivity of leukemia cells to the killing effects of chemotherapy in vivo. Treatment outcome was unrelated to c-myc expression.