Artificially-reared female rats show reduced prepulse inhibition and deficits in the attentional set shifting task - reversal of effects with maternal-like licking stimulation
Artificially-reared female rats show reduced prepulse inhibition and deficits in the attentional set shifting task - reversal of effects with maternal-like licking stimulation
复制标题
DOI：
10.1016/s0166-4328(03)00206-7
复制
发表时间：
2004-01-05
影响因子：
2.7
通讯作者：
Fleming, AS
中科院分区：
文献类型：
--
作者：
Lovic, V;Fleming, AS
哺乳动物的神经系统是可塑的，特别是在发育的早期阶段。在没有母亲的情况下饲养的新生大鼠，长大后对自己的后代表现出缺乏母性的行为。本研究的目的是评估在人工饲养（AR）雌性大鼠中观察到的母体行为缺陷是否与注意力缺陷相关。通过人工饲养，将雌性大鼠幼仔与母亲一起饲养或不与母亲一起饲养。在成年期，评估了大鼠的母性行为和注意力任务（惊吓反应的前脉冲抑制（PPI）和注意力定势转移任务）的表现。我们发现，AR大鼠表现出：减少母亲舔小狗和时间蹲在小狗，更少的PPI，和更多的试验，以标准在几个阶段的注意力转移任务。在人工饲养过程中，提供“母亲般的舔”刺激的人工饲养大鼠与母亲饲养的大鼠没有显着差异。此外，母亲的行为与PPI和注意定势转换任务的绩效之间存在显著相关。(C)2003 Elsevier B.V.保留所有权利。
Mammalian nervous system is plastic, particularly during early stages of development. Rat neonates that are reared without mothers, grow up to show deficient maternal behavior towards their own offspring. The purpose of this study was to assess whether maternal behavior deficits, seen in artificially-reared (AR) female rats, are associated with attentional deficits. Female rat pups were reared with or without their mothers, through artificial rearing. In adulthood, rats' maternal behavior and performance on attentional tasks (prepulse inhibition (PPI) of the startle response and attentional set shifting task) were assessed. We found that AR rats showed: decreased maternal pup licking and time crouching over pups, less PPI, and more trials to criterion in several stages of the attentional set shifting task. Artificially-reared rats that were provided with 'maternal-like licking' stimulation, during artificial rearing, were not significantly different from mother-reared rats. In addition, there was a significant correlation between maternal behaviors and both PPI and the performance in the attentional set shifting task. (C) 2003 Elsevier B.V. All rights reserved.