Sphingosine‐1‐phosphate selectively activates vagal afferent C‐fiber subtype in guinea pig esophagus
Sphingosine‐1‐phosphate selectively activates vagal afferent C‐fiber subtype in guinea pig esophagus
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DOI：
10.1111/nmo.13359
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发表时间：
2018-09
影响因子：
3.5
通讯作者：
Xiaoyun Yu;Mayur J. Patil;Mingwei Yu;Y. Liu;J. Wang;B. Undem;Shaoyong Yu
中科院分区：
文献类型：
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作者：
Xiaoyun Yu;Mayur J. Patil;Mingwei Yu;Y. Liu;J. Wang;B. Undem;Shaoyong Yu
炎症介质对内脏传入神经的激活和敏化在内脏伤害感受中发挥重要作用。 1-磷酸鞘氨醇 (S1P) 是一种具有细胞内和细胞外功能的脂质。在细胞外，它可以通过与 S1P 受体相互作用而充当自体激素。本研究旨在确定 S1P 对食管迷走神经传入神经功能的影响。
Activation and sensitization of visceral afferent nerves by inflammatory mediators play important roles in visceral nociception. Sphingosine‐1‐phosphate (S1P) is a lipid with intracellular and extracellular functions. Extracellularly, it can act as an autacoid via interactions with S1P receptors. The present study aims to determine the effect of S1P on esophageal vagal afferent nerve functions.