Bench to bedside: A role for erythropoietin in sepsis.
Bench to bedside: A role for erythropoietin in sepsis.
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DOI：
10.1186/cc9049
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Sharples E
中科院分区：
文献类型：
--
作者：
Walden AP;Young JD;Sharples E
脓毒症是对感染的全身性炎症反应，可导致多器官功能障碍综合征，并伴有高死亡率、发病率和健康成本。促红细胞生成素由于其对红细胞及其前体细胞的抗凋亡作用而被公认为用于肾衰竭贫血的治疗。促红细胞生成素的造血外作用包括血管加压、抗凋亡、细胞保护和免疫调节作用，所有这些都可以证明对脓毒症有益。在几种动物模型中已显示出器官功能障碍的减弱，并且其血管加压作用已在实验室和临床环境中得到充分表征。促红细胞生成素在单器官疾病中的临床试验表明具有良好的细胞保护作用，虽然没有在脓毒症患者中进行随机试验，但危重患者贫血研究的高质量数据提供了其药代动力学和潜在危害的有用信息。一项研究促红细胞生成素微血管效应的观察性队列研究正在进行中，证据将支持进一步的II期和III期临床试验，研究该分子作为脓毒症的预防性治疗。
Sepsis is the systemic inflammatory response to infection and can result in multiple organ dysfunction syndrome with associated high mortality, morbidity and health costs. Erythropoietin is a well-established treatment for the anaemia of renal failure due to its anti-apoptotic effects on red blood cells and their precursors. The extra-haemopoietic actions of erythropoietin include vasopressor, anti-apoptotic, cytoprotective and immunomodulating actions, all of which could prove beneficial in sepsis. Attenuation of organ dysfunction has been shown in several animal models and its vasopressor effects have been well characterised in laboratory and clinical settings. Clinical trials of erythropoietin in single organ disorders have suggested promising cytoprotective effects, and while no randomised trials have been performed in patients with sepsis, good quality data exist from studies on anaemia in critically ill patients, giving useful information of its pharmacokinetics and potential for harm. An observational cohort study examining the microvascular effects of erythropoietin is underway and the evidence would support further phase II and III clinical trials examining this molecule as an adjunctive treatment in sepsis.
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影响因子：
3.8
作者：
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通讯作者：
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作者：
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DOI：
10.1097/00005373-199312000-00007
发表时间：
1993-12-01
影响因子：
--
作者：
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通讯作者：
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影响因子：
158.5
作者：
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通讯作者：
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