Paired-Associative Stimulation-Induced Long-term Potentiation-Like Motor Cortex Plasticity in Healthy Adolescents.
Paired-Associative Stimulation-Induced Long-term Potentiation-Like Motor Cortex Plasticity in Healthy Adolescents.
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DOI：
10.3389/fpsyt.2017.00095
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发表时间：
2017
影响因子：
4.7
通讯作者：
Daskalakis ZJ
中科院分区：
文献类型：
--
作者：
Lee JC;Croarkin PE;Ameis SH;Sun Y;Blumberger DM;Rajji TK;Daskalakis ZJ
本研究的目的是评估使用配对联想刺激(PAS)研究青少年兴奋性和抑制性可塑性的可行性，同时考察可能调节可塑性的变量(如性别和环境)。我们招募了34名健康青少年(年龄13-19岁，男13名，女21名)。为评价兴奋性可塑性，我们比较了PAS前后0、15、30 单脉冲经颅磁刺激诱发的平均运动诱发电位(MEP)。为了评价抑制可塑性，我们在0、15和30 的PAS前和PAS后评估了单次脉冲TMS在收缩手中诱发的皮层静默期。所有参与者都完成了PAS程序。未发生不良事件。对PAS的耐受性很好。PAS引起PAS后MEP与PAS前MEP波幅的比值在PAS后各间期均显著增加(p <； 0.01)。社会经济地位和性别均与术后MEP改变无关。PAS能显著延长雄性CSP，但不能引起雌性CSP延长。PAS是一种可行、安全、耐受性好的青少年运动皮质可塑性指标。性别可能影响PAS引起的皮层抑制的改变。PAS是一种安全且耐受性良好的健康青少年，可能成为研究青少年神经可塑性的新工具。
The objective of this study was to evaluate the feasibility of using paired-associative stimulation (PAS) to study excitatory and inhibitory plasticity in adolescents while examining variables that may moderate plasticity (such as sex and environment). We recruited 34 healthy adolescents (aged 13–19, 13 males, 21 females). To evaluate excitatory plasticity, we compared mean motor-evoked potentials (MEPs) elicited by single-pulse transcranial magnetic stimulation (TMS) before and after PAS at 0, 15, and 30 min. To evaluate inhibitory plasticity, we evaluated the cortical silent period (CSP) elicited by single-pulse TMS in the contracted hand before and after PAS at 0, 15, and 30 min. All participants completed PAS procedures. No adverse events occurred. PAS was well tolerated. PAS-induced significant increases in the ratio of post-PAS MEP to pre-PAS MEP amplitudes (p < 0.01) at all post-PAS intervals. Neither socioeconomic status nor sex was associated with post-PAS MEP changes. PAS induced significant CSP lengthening in males but not females. PAS is a feasible, safe, and well-tolerated index of adolescent motor cortical plasticity. Gender may influence PAS-induced changes in cortical inhibition. PAS is safe and well tolerated by healthy adolescents and may be a novel tool with which to study adolescent neuroplasticity.