Effect of unitization on associative recognition in amnesia
Effect of unitization on associative recognition in amnesia
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DOI：
10.1002/hipo.20257
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发表时间：
2007-01-01
期刊：
影响因子：
3.5
通讯作者：
Normani, Kenneth A.
中科院分区：
文献类型：
--
作者：
Quamme, Joel R.;Yonelinas, Andrew P.;Normani, Kenneth A.
我们研究了遗忘症患者的联想识别表现是如何通过使用统一化（即整体）编码、策略来调节的，以及统一化效果与保留基于熟悉性的识别的相关程度。参与者将单词对作为句子中单独的词汇单位（即非统一）或复合词（统一）进行研究。在标准识别指令下，正常对照和左颞叶损伤的患者（之前确定记忆力和熟悉度均受损）在组合化和非组合化配对方面没有表现出差异，而缺氧者（之前确定记忆力受损但熟悉度相对保留）显示出组合化配对比非组合化配对具有优势。这种效应在正常健康参与者的指导下重现，限制对熟悉程度判断的反应。结果表明，单元化可能会调节一些健忘症患者所表现出的联想识别障碍的程度，并且其效果与保留的熟悉能力有关。讨论了这些结果与海马体在记忆联想中的重要性的争论的相关性。 (c) 2007 年 Wiley-Liss, Inc.
We examined how associative recognition performance in amnesic patients is mediated by use of a unitized (i.e., holistic) encoding, strategy, and the degree to which the unitization effect is related to sparing of familiarity-based recognition. Participants studied word pairs as either separate lexical units in sentences (i.e., nonunitized) or as compounds (unitized). Under standard recognition instructions, normal controls and patients with left-temporal lobe damage (previously determined to have impairments in both recollection and familiarity) showed no difference for unitized and nonunitized pairs, whereas hypoxics (previously, determined to have impaired recollection but relatively preserved familiarity) showed an advantage of unitized over nonunitized pairs. This effect was reproduced in normal healthy participants under instructions to, restrict responses to judgments of familiarity. The results indicate that unitization may mediate the degree of associative recognition impairment exhibited by some amnesic patients, and that the effect is related to, preserved familiarity capacity. The relevance of the results to the debate over the importance of the hippocampus in memory for associations is discussed. (c) 2007 Wiley-Liss, Inc.