Lipid Vesicles Induced Ordered Nanoassemblies of Janus Nanoparticles
Lipid Vesicles Induced Ordered Nanoassemblies of Janus Nanoparticles
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脂质囊泡诱导 Janus 纳米粒子的有序纳米组装体
DOI：
10.1039/d2sm01693a
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发表时间：
2023
期刊：
影响因子：
3.4
通讯作者：
Laradji, Mohamed
中科院分区：
文献类型：
--
作者：
Zhu, Yu;Sharma, Abash;Spangler, Eric J;Carrillo, Jan Michael;Kumar, Sunil P.;Laradji, Mohamed
由于许多先进的应用需要特定的纳米粒子组件（NPs），因此已经做出了相当大的努力来制造具有特定几何形状的纳米组件。虽然纳米组件可以通过自上而下的方法制造，但最近的进展表明，复杂的纳米组件也可以通过自组装获得，例如由DNA链介导。在这里，我们通过广泛的分子动力学模拟表明，NPs的高度有序的自组装可以通过它们与脂质囊泡（lv）的粘附来介导。具体来说，考虑Janus NPs是为了控制它们被LV包裹的数量。纳米组件的特定几何形状是NPs与粘附在LV上的NPs数量之间曲率介导的有效斥力的结果。NPs在LV上排列成满足欧拉多面体公式上限的多面体，包括几个三角体和三个柏拉图体，分别对应四面体、八面体和二十面体。
Since many advanced applications require specific assemblies of nanoparticles (NPs), considerable efforts have been made to fabricate nanoassemblies with specific geometries. Although nanoassemblies can be fabricated through top-down approaches, recent advances show that intricate nanoassemblies can also be obtained through self-assembly, mediated for example by DNA strands. Here, we show, through extensive molecular dynamics simulations, that highly ordered self-assemblies of NPs can be mediated by their adhesion to lipid vesicles (LVs). Specifically, Janus NPs are considered so that the amount by which they are wrapped by the LV is controlled. The specific geometry of the nanoassembly is the result of effective curvature-mediated repulsion between the NPs and the number of NPs adhering to the LV. The NPs are arranged on the LV into polyhedra which satisfy the upper limit of Euler's polyhedral formula, including several deltahedra and three Platonic solids, corresponding to the tetrahedron, octahedron, and icosahedron.