GOToolBox: functional analysis of gene datasets based on Gene Ontology.
GOToolBox: functional analysis of gene datasets based on Gene Ontology.
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DOI：
10.1186/gb-2004-5-12-r101
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发表时间：
2004
期刊：
影响因子：
12.3
通讯作者：
Jacq B
中科院分区：
文献类型：
--
作者：
Martin D;Brun C;Remy E;Mouren P;Thieffry D;Jacq B
提供了一些工具，用于识别在数据集中过度表达或表达不足的基因本体（Gene Ontology，GO）术语，按功能对基因进行聚类，并找到具有相似注释的基因。
我们基于基因本体资源开发了一些方法和工具，能够识别基因数据集中统计学上过度表达或表达不足的术语；对一组内功能相关的基因进行聚类；以及检索与查询基因具有相同注释的基因。基因本体注释也可限定在一个精简的层次结构或本体的给定级别。源代码可应要求提供，并依据GPL许可证分发。
Tools are presented to identify Gene Ontology terms that are over- or under-represented in a dataset, to cluster genes by function and to find genes with similar annotations. We have developed methods and tools based on the Gene Ontology (GO) resource allowing the identification of statistically over- or under-represented terms in a gene dataset; the clustering of functionally related genes within a set; and the retrieval of genes sharing annotations with a query gene. GO annotations can also be constrained to a slim hierarchy or a given level of the ontology. The source codes are available upon request, and distributed under the GPL license.