Anti-Stress, Behavioural and Magnetoencephalography Effects of an l-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial
Anti-Stress, Behavioural and Magnetoencephalography Effects of an l-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial
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L-茶氨酸营养饮料的抗压力、行为和脑磁图作用：随机、双盲、安慰剂对照、交叉试验
作者：
D. White;Suzanne de Klerk;W. Woods;Shakuntla V Gondalia;C. Noonan;A. Scholey
L-茶氨酸（γ-谷氨酰乙酰胺）是主要在绿色茶树中发现的氨基酸。本研究探讨了基于l-茶氨酸的营养饮料对认知应激源的情绪反应的影响。其他措施包括使用脑磁图（MEG）评估认知能力和静息状态α振荡活动。34名18-40岁的健康成年人参加了这项双盲、安慰剂对照、平衡交叉研究。与安慰剂相比，服用l-茶氨酸饮料一小时后，主要结果指标，对多任务认知应激源的主观应激反应显著降低。积极治疗后给药后3小时，唾液皮质醇对应激源的反应降低。未观察到给药相关的认知表现变化。与给药后2小时的安慰剂相比，活性治疗后后部MEG传感器的静息状态α振荡活动显著更大;然而，这种效应仅在特质焦虑较高的患者中明显。静息状态α振荡活动的这种变化与主观应激反应或皮质醇反应的变化无关，这表明需要进一步研究来评估静息α活动中这些治疗相关变化的功能相关性。这些发现进一步支持l-茶氨酸的抗应激作用。
l-theanine (γ-glutamylethylamide) is an amino acid found primarily in the green tea plant. This study explored the effects of an l-theanine-based nutrient drink on mood responses to a cognitive stressor. Additional measures included an assessment of cognitive performance and resting state alpha oscillatory activity using magnetoencephalography (MEG). Thirty-four healthy adults aged 18–40 participated in this double-blind, placebo-controlled, balanced crossover study. The primary outcome measure, subjective stress response to a multitasking cognitive stressor, was significantly reduced one hour after administration of the l-theanine drink when compared to placebo. The salivary cortisol response to the stressor was reduced three hours post-dose following active treatment. No treatment-related cognitive performance changes were observed. Resting state alpha oscillatory activity was significantly greater in posterior MEG sensors after active treatment compared to placebo two hours post-dose; however, this effect was only apparent for those higher in trait anxiety. This change in resting state alpha oscillatory activity was not correlated with the change in subjective stress response or the cortisol response, suggesting further research is required to assess the functional relevance of these treatment-related changes in resting alpha activity. These findings further support the anti-stress effects of l-theanine.
DOI：
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发表时间：
1970
期刊：
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影响因子：
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作者：
C. Spielberger;R. Gorsuch;R. Lushene
通讯作者：
C. Spielberger;R. Gorsuch;R. Lushene
影响因子：
3.7
作者：
Groppe DM;Urbach TP;Kutas M
通讯作者：
Kutas M