Centromere-localized Aurora B kinase is required for the fidelity of chromosome segregation
Centromere-localized Aurora B kinase is required for the fidelity of chromosome segregation
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着丝粒定位的 Aurora B 激酶对于染色体分离的保真度是必需的
DOI：
10.1083/jcb.201907092
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发表时间：
2020-02-03
影响因子：
7.8
通讯作者：
Wang, Fangwei
中科院分区：
文献类型：
--
作者：
Liang, Cai;Zhang, Zhenlei;Wang, Fangwei
Aurora B 定位于着丝粒，但尚不清楚这是否会影响有丝分裂中的染色体分离。梁等人。发现两个磷酸组蛋白标记分别将 Aurora B 招募到着丝粒，并冗余地发挥忠实染色体分离的作用。着丝粒处 H3pT3 和 H2ApT120 依赖的 Aurora B 池的丢失会降低纠错效率并增加后期的滞后染色体。
Aurora B localizes to centromeres, but it is unclear if this influences chromosome segregation in mitosis. Liang et al. find that two phospho-histone marks separately recruit Aurora B to centromeres and act redundantly for faithful chromosome segregation. Loss of H3pT3- and H2ApT120-dependent pools of Aurora B at centromeres diminishes error correction efficiency and increases lagging chromosomes in anaphase.