Cancer stem cells: A shifting subpopulation of cells with stemness?
Cancer stem cells: A shifting subpopulation of cells with stemness?
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癌症干细胞：具有干性的细胞亚群的变化？
DOI：
10.1016/j.mehy.2013.01.009
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发表时间：
2013-05-01
影响因子：
4.7
通讯作者：
Liu, Shanrong
中科院分区：
文献类型：
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作者：
Hu, Yijun;Yu, Xiya;Liu, Shanrong
癌变和肿瘤细胞长期以来一直被认为是由基因突变产生的，直到癌症干细胞（CSC）模型的出现。这个相对较新的模型揭示了恶性肿瘤形成和维持的另一层复杂性。然而，这些难以追踪的亚群不仅难以在分子水平上理解，而且还阻碍了基于 CSC 的新型癌症疗法的开发。先前研究积累的证据表明，CSC 可能源自成体干细胞 (SCC) 或分化的祖细胞，并且它们不断重建其生态位；这些因素是其频率和生物标志物表达变异的基础。因此，我们提出这样的假设：CSC 具有不断进化的特征。在肿瘤发生过程中，CSC的特性可能会发生变化，从而呈现出“移动的目标”。我们还建议，结合传统细胞表面标记和转录因子靶向方法来识别“干性”的多方面综合策略应该可以更好地分离和表征 CSC。还提供了检验该假设的相应实验室方法。 (C) 2013 Elsevier Ltd. 保留所有权利。
Carcinogenesis and tumor cells had long been thought to be produced by genetic mutations, until the emergence of the cancer stem cell (CSC) model. This relatively new model reveals another layer of complexity in malignancy formation and maintenance. However, these hard-to-track subpopulations have not only been challenging to understand at the molecular level but have also prevented the development of novel CSC-based cancer therapies. Accumulating evidence from previous studies has suggested that CSCs might be derived from either somatic stem cells (SCCs) or differentiated progenitor cells and that they constantly reestablish their niches; these factors underlie the variability in their frequencies and biological marker expression. Therefore, we present the hypothesis that CSCs possess constantly evolving features. During tumorigenesis, the characteristics of the CSCs may change, thus presenting a "moving target". We also suggest that a multifaceted, integrated strategy combining traditional cell surface markers and transcriptional factor targeting methods to identify "stemness" should lead to the better isolation and characterization of CSCs. Corresponding laboratory approaches to test this hypothesis are also provided. (C) 2013 Elsevier Ltd. All rights reserved.