Increased risk of tuberculosis with human T-lymphotropic virus-1 infection - A case-control study
Increased risk of tuberculosis with human T-lymphotropic virus-1 infection - A case-control study
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DOI：
10.1097/01.qai.0000174252.73516.7a
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发表时间：
2005-12-15
影响因子：
3.6
通讯作者：
Barreto, ML
中科院分区：
文献类型：
--
作者：
Marinho, J;Galvao-Castro, B;Barreto, ML
目的：研究人类嗜T淋巴细胞病毒1型（HTLV-1）感染是否增加结核病的风险。设计：病例对照研究。地点：巴西萨尔瓦多市。参与者：共375例结核病患者（病例）和378例非结核病个体（对照组），按年龄和性别匹配。主要结果测量：肺或淋巴结结核。主要暴露：人HTLV-1感染。结果：结核病组和对照组HTLV-1感染率分别为4.27%（16/375）和1.32%（5/378），粗比值比为3.31（95%CI，1.20-9.13），校正比值比为3.01（95%CI，1.06-8.58）。这可能对结核病控制具有HTLV-1高流行率的疾病场所具有意义。
Objectives: To investigate whether infection with human T-lymphotropic virus type 1 (HTLV-1) increases the risk of tuberculosis.Design: A case-control Study.Setting: City of Salvador, Brazil.Participants: A total of 375 patients with tuberculosis (cases) and 378 individuals without tuberculosis (controls), matched by age and sex.Main Outcome Measure: Tuberculosis Of lung or lymph node.Main Exposure: Human HTLV-1 infection.Results: The prevalence of HTLV-1 infection was 4.27% (16/375) in patients with tuberculosis and 1.32% (5/378) in controls, resulting in a crude odds ratio of 3.31 (95% CI, 1.20-9.13) and all adjusted odds ratio of 3.01 (95% CI, 1.06-8.58).Conclusion: HTLV-1 infection is associated with a first diagnosis of tuberculosis. This may have implications for tuberculosis Control ill places with high prevalence of HTLV-1.