Stability of Blood Pressure Rank and Urinary Kallikrein Concentration in Childhood: An Eight-Year Follow-Up
Stability of Blood Pressure Rank and Urinary Kallikrein Concentration in Childhood: An Eight-Year Follow-Up
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DOI：
10.1161/01.cir.58.5.908
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发表时间：
1978-11
期刊：
影响因子：
37.8
通讯作者：
S. Zinner;H. Margolius;B. Rosner;E. Kass
中科院分区：
文献类型：
--
作者：
S. Zinner;H. Margolius;B. Rosner;E. Kass
摘要
先前对721名2 - 14岁儿童进行的研究表明，儿童血压存在家族聚集性，并且在四年期间，随访血压与初始血压之间存在显著的回归系数（b = 0.25）。尿激肽释放酶浓度（UKal）在家族中也存在聚集性，黑人儿童的该浓度低于白人儿童，且与血压呈负相关。
在同一队列中进行了进一步的研究。在初始血压测量7 - 8年后以及首次尿激肽释放酶测量3 - 4年后，对129个家庭的484名儿童再次测量了这些变量。再次发现血压和尿激肽释放酶存在家族聚集性。通过第三次调查的血压值与前两次调查的血压值显著相关这一发现，证明了血压的追踪性。第三次调查的随机尿样中激肽释放酶浓度与第二次调查的浓度相关（r = 0.499），并且黑人儿童的该浓度再次显著低于白人儿童（对数 = 3.84 ± 0.8对4.37 ± 0.7；P < 0.001）。在白人和黑人儿童中，尿激肽释放酶/肌酐浓度与血压之间均存在显著的负相关关系。
因此，在为期8年的观察期间，儿童的血压家族聚集性、血压等级以及随机尿样中激肽释放酶的浓度相对稳定。这项研究在正常儿童的自由生活人群中表明，血压与一种参与产生强效血管扩张肽且与成人高血压相关的酶之间存在稳定的关系。
SUMMARY Previous studies in a population of 721 children aged 2-14 years demonstrated the familial aggregation of blood pressure in children, and a significant regression coefficient (b = 0.25) of follow-up on initial blood pressures over a four-year period. Urinary kallikrein concentration (UKal) also aggregated in families, was lower in black than in white children and was inversely related to blood pressure.Further studies in the same cohort have been conducted. These variables were again measured in 484 children in 129 families seven to eight years after the initial blood pressure and three to four years after the original UKal measurements were made.Familial aggregation again was found for blood pressure and urinary kallikrein. Blood pressure tracking was demonstrated by the finding that blood pressure scores at the third survey were related significantly to those at both previous surveys.Kallikrein concentrations in casual urines at Survey 3 were related to those obtained at Survey 2 (r = 0.499), and were again significantly lower in black than in white children (log = 3.84 ± 0.8 vs 4.37 ± 0.7; P < 0.001). There were significant inverse relations between UKal/creatinine concentration and blood pressure in both white and black children.Thus, familial aggregation of blood pressure, blood pressure rank and concentration of kallikrein in casual urine specimens are relatively stable in children over an eight-year period of observation. This study demonstrates in a free living population of normal children, a stable relation between blood pressure and an enzyme which is involved in the production of potent vasodilator peptides and is related to hypertension in adults.