Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis.
Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis.
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DOI：
10.1093/oxfordjournals.qjmed.a068882
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发表时间：
1994-11
期刊：
影响因子：
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通讯作者：
R. Luqmani;P. Bacon;R. Moots;B. A. Janssen;A. Pall;P. Emery;C. Savage;D. Adu
中科院分区：
文献类型：
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作者：
R. Luqmani;P. Bacon;R. Moots;B. A. Janssen;A. Pall;P. Emery;C. Savage;D. Adu
尽管积极治疗改善了预后，但血管炎患者的持续发病率强调了准确评估疾病的必要性。我们设计了一个疾病活动的临床指数，并评估其在几种形式的坏死性血管炎中的应用。加权评分基于九个独立器官系统的症状和体征。疾病特征仅在可归因于活动性血管炎时进行评分。伯明翰血管炎活动性评分（BVAS）与其他两种已发表的血管炎活动性评分、医生总体评估（PGA）、结局和疾病活动性血清学标志物进行比较。在一项对213例不同形式血管炎的连续患者进行的横断面研究中，所有107例临床评估完全良好的血管炎患者的BVAS评分均为0。22例治疗前活动性血管炎患者的中位评分为7.5（范围4-30），69例治疗中活动性疾病患者的中位评分为10（1-29）。在12名死亡者中，死亡前的中位评分为20.5（9-30）。在一项系列前瞻性研究中，30例病例记录了活动性疾病发作。在疾病活动期，中位BVAS值显著高于缓解期（15 [范围3-32] vs. 0 [0-2]，p < 0.001）; CRP值也是如此（80 [9-361] vs. 13.5 [5-68]，p < 0.001）。而红细胞沉降率（ESR）、血红蛋白（Hb）或血管性血友病因子（VWF）则不然。（250字处删节）
The continuing morbidity of patients with vasculitis, despite the improved prognosis with aggressive therapy, underlines the need for accurate disease assessment. We have devised a clinical index of disease activity, and evaluated its use in several forms of necrotizing vasculitis. The weighted score is based on symptoms and signs in nine separate organ systems. Disease features are only scored if they are attributable to active vasculitis. The Birmingham Vasculitis Activity Score (BVAS) was compared with two other published vasculitis activity scores, with the physician's global assessment (PGA), with outcome, and with serological markers of disease activity. In a cross-sectional study of 213 consecutive patients with different forms of vasculitis, all 107 vasculitis patients who were judged completely well on clinical assessment had a BVAS score of 0. Twenty-two patients with active vasculitis prior to treatment had a median score of 7.5 (range 4-30) and 69 with active disease on treatment had a median score of 10 (1-29). Of the 12 who died, median score immediately prior to death was 20.5 (9-30). In a serial prospective study, 30 cases had documented episodes of active disease. During periods of disease activity, the median BVAS values were significantly higher than in remission (15 [range 3-32] vs. 0 [0-2], p < 0.001); the same was true for CRP values (80 [9-361] vs. 13.5 [5-68], p < 0.001). This was not true for erythrocyte sedimentation rate (ESR), haemoglobin (Hb) or von Willebrand factor (VWF).(ABSTRACT TRUNCATED AT 250 WORDS)