Glycosylated Serum Protein May Improve Our Ability to Predict Endothelial and Erectile Dysfunction in Nonorganic Patients
Glycosylated Serum Protein May Improve Our Ability to Predict Endothelial and Erectile Dysfunction in Nonorganic Patients
复制标题
糖基化血清蛋白可以提高我们预测非器质性患者内皮和勃起功能障碍的能力
DOI：
10.1111/j.1743-6109.2010.02141.x
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发表时间：
2011-03-01
影响因子：
3.5
通讯作者：
Zhang, Yuanyuan
中科院分区：
文献类型：
--
作者：
Huang, Yanping;Sun, Xiangzhou;Zhang, Yuanyuan
前言：勃起功能障碍（艾德）的早期预测对阳痿的治疗至关重要。目的探讨糖化血清蛋白（GSP）对青年男性艾德患者的早期预测价值。方法对150例青年男性艾德患者和27例健康男性ED患者进行国际勃起功能指数（IIEF-5）、糖化血清蛋白（GSP艾德的病因、艾德的影响因素或危险因素、血管参数和血清生化标志物。入选52例艾德患者，年龄20-40岁，病因不明，22例年龄匹配的正常受试者。两组的进一步评估集中在血管内皮功能和糖代谢状态.主要结果测量. IIEF-5评分，血流介导的扩张（FMD），和GSP之间的关系进行了分析，在病例与对照组，使用皮尔逊相关性和多元线性回归分析.结果.在基线特征，心血管风险，和传统的生物标志物之间没有显着差异被发现测试组和对照组，空腹血糖水平除外（4.69 ± 0.50 vs. 4.29 ± 0.48，P = 0.003）。FMD值与IIEF-5评分呈正相关（r = 0.629，P < 0.001）。艾德组GSP水平明显高于对照组，并与IIEF-5评分（r =-0.504，P < 0.001）和FMD值（r =-0.469，P < 0.001）呈负相关。这些参数独立预测艾德的存在。FMD > 11.55%排除艾德的阳性预测值和GSP > 210.50 mg/L诊断艾德的阳性预测值分别为86.4%和86.4%（曲线下面积[AUC]：0.942，特异性：88.4%）和84.5%（AUC：0.864，特异性：72.7%），结论：潜在的糖代谢紊乱和亚临床内皮功能障碍可作为年轻艾德患者器质性艾德的早期标志，已知的相关风险因素。GSP水平可能提高我们预测内皮功能障碍和勃起功能障碍的能力。Huang Y，Sun X，Liu G，Yao F，Zheng F，Dai Y，Tu X，Xie X，Deng L，Zhang D，Zhang Y，Bian J，Gao Y，Ye Y，Deng C，and Zhang Y.糖化血清蛋白可以提高我们预测非器质性患者内皮功能和勃起功能障碍的能力。J Sex Med 2011;8：840-850.
Introduction.Early prediction of erectile dysfunction (ED) is critical in the treatment of impotence. Underlying pathogenesis may be the reason for ED without organic causes in young men.Aim.We evaluated the early predictive value of glycosylated serum protein (GSP) in young patients whose ED was diagnosed as "nonorganic" in origin according to general criteria.Methods.A total of 150 young men with ED and 27 healthy men without ED were evaluated, including International Index of Erectile Function-5 (IIEF-5), causes of ED, influential or risk factors for ED, vascular parameters, and serum biochemical markers. Fifty-two ED patients aged 20-40 years without known etiology and 22 age-matched normal subjects were enrolled. The further assessment of two groups focused on vascular endothelial function and glycometabolic state.Main Outcome Measures.Relationships among the IIEF-5 scores, flow-mediated dilation (FMD), and GSP were analyzed in cases vs. controls, using Pearson's correlation and multiple linear regression analysis.Results.No significant differences in baseline characteristics, cardiovascular risks, and conventional biomarkers were found between testing and control groups, except fasting blood glucose level (4.69 +/- 0.50 vs. 4.29 +/- 0.48, P = 0.003). FMD values were significantly reduced in cases compared with controls and correlated positively with IIEF-5 scores (r = 0.629, P < 0.001). GSP levels were significantly increased in the ED cases compared with controls and correlated negatively with IIEF-5 scores (r = -0.504, P < 0.001) and FMD values (r = -0.469, P < 0.001). These parameters independently predicted ED presence. The positive predictive value of FMD > 11.55% for excluding ED and of GSP > 210.50 mg/L for diagnosing ED were 86.4% (area under the curve [AUC]: 0.942, specificity: 88.4%) and 84.5% (AUC: 0.864, specificity: 72.7%), respectively.Conclusions.Underlying glycometabolic disorder and subclinical endothelial dysfunction may be served as early markers for organic ED in young ED patients without well-known related risk factors. GSP level may improve our ability to predict endothelial dysfunction and erectile dysfunction. Huang Y, Sun X, Liu G, Yao F, Zheng F, Dai Y, Tu X, Xie X, Deng L, Zhang D, Zhang Y, Bian J, Gao Y, Ye Y, Deng C, and Zhang Y. Glycosylated serum protein may improve our ability to predict endothelial and erectile dysfunction in non-organic patients. J Sex Med 2011;8:840-850.