Voxel-based correlation of (18)F-THK5351 accumulation with gray matter structural networks in cognitively normal older adults.
Voxel-based correlation of (18)F-THK5351 accumulation with gray matter structural networks in cognitively normal older adults.
复制标题
认知正常老年人中（18）F-THK 5351蓄积与灰质结构网络的基于体素的相关性
DOI：
10.1016/j.ensci.2021.100343
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发表时间：
2021-06
期刊：
影响因子：
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通讯作者：
Matsuda H
中科院分区：
文献类型：
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作者：
Shigemoto Y;Sone D;Maikusa N;Kimura Y;Suzuki F;Fujii H;Sato N;Matsuda H
这项研究的目的是评估认知正常(CN)老年人的灰质磁共振成像(MRI)扫描得出的tau相关结构网络指标。我们招募了47名淀粉样蛋白阴性的CN老年人(平均年龄±标准差，65.0±77.9岁；26名女性)。所有受试者均接受了3DT1加权MRI、11C-匹兹堡化合物B和18F-THK5351正电子发射断层扫描。计算了四个局部网络度量(介数中心度、聚类系数、特征路径长度和度数)，并在单个脑图像上进行渲染。然后，我们在体素水平上评估了18F-THK5351正电子发射断层扫描图像和局部网络度量图像之间的相关性。在双侧尾状核，四种局域网络指标与18F-THK5351呈显著正相关。我们的发现表明，tau和CN老年人的神经炎症可能会影响尾状核中的灰质结构网络。健康老年人18F-THK5351与网络指标图像的局部相关性研究18F-THK5351与尾状核网络改变呈正相关。Tau和神经炎症可能影响尾状核的结构网络。
The aim of this study was to evaluate tau-related structural network metrics derived from gray matter magnetic resonance imaging (MRI) scans in cognitively normal (CN) older adults. We recruited 47 amyloid-negative CN older adults (mean age ± standard deviation, 65.0 ± 7.9 years; 26 women). All participants underwent 3D T1-weighted MRI and 11C-Pittsburgh compound-B and 18F-THK5351 positron emission tomography scans. Four local network metrics (betweenness centrality, clustering coefficient, characteristic path length, and degree) were computed and rendered on individual brain images. We then evaluated the correlations between 18F-THK5351 positron emission tomography images and local network metric images at the voxel level. Significant positive correlations of the four local network metrics with 18F-THK5351 were detected in the bilateral caudate. Our findings suggest that tau and neuroinflammation in CN older adults may influence the gray matter structural network in the caudate. Local correlation of 18F-THK5351 and network metrics images in healthy elderly. Positive correlation between 18F-THK5351and network changes in the caudate. Tau and neuroinflammation may influence structural network in the caudate.