Characterization of the IgG antibody response to timothy grass pollen antigens.
Characterization of the IgG antibody response to timothy grass pollen antigens.
复制标题
对梯牧草花粉抗原的 IgG 抗体反应的表征。
DOI：
10.1159/000233863
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Turner,KJ
中科院分区：
文献类型：
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作者：
Malley,A;Hopkins,SJ;Turner,KJ
测定了几个品系小鼠抗梯牧草花粉抗原B（Ag B）的IgG和IgE抗体反应。两种反应均表现出相当大的变异性，并选择（CBA/J × C57 BL/6）F1小鼠用于后续实验。抗独特型抗体诱导的T抑制细胞几乎完全抑制AgB特异性IgE，但IgG反应没有改变。用光氧化的AgB（Ox-AgB）进行的进一步研究表明，IgG反应针对天然抗原和Ox-AgB上表达的抗原决定簇。我们的数据表明，AgB具有两个不同的抗原决定簇，一个诱导IgE反应，一个诱导IgG反应。
The IgG and IgE antibody responses against timothy grass pollen antigen B (AgB) in several mouse strains were determined. Considerable variability in both responses was demonstrated, and (CBA/J × C57BL/6)F1mice were selected for use in subsequent experiments. Anti-idiotypic-antibody-induced T suppressor cells almost completely suppressed AgB-specific IgE, but the IgG response was not altered. Further studies with photooxidized AgB (Ox-AgB) indicated that the IgG response was directed against an antigenic determinant expressed on both native antigen and Ox-AgB. Our data indicates that AgB possesses two distinct antigenic determinants, one that induces an IgE response, and one that induces an IgG response.