Association between colonization with group B streptococci during pregnancy and preterm delivery among Danish women
Association between colonization with group B streptococci during pregnancy and preterm delivery among Danish women
复制标题
DOI：
10.1067/mob.2001.109936
复制
发表时间：
2001-02-01
影响因子：
9.8
通讯作者：
Schuchat, A
中科院分区：
文献类型：
--
作者：
Feikin, DR;Thorsen, P;Schuchat, A
目的：探讨B群链球菌定植与早产的关系。研究设计：在丹麦欧登塞的一家医院进行的这项前瞻性研究中，在所有妇女妊娠少于或等于24周时，从早产妇女分娩时，以及从足月分娩妇女的随机样本中获得宫颈阴道培养。结果：2846例单胎分娩。小于或等于妊娠24周的B组链球菌定植与早产之间无显著关联。在对早产危险因素进行校正后，早产妇女（12/ 84,14%）比足月分娩妇女（22/300,7%；校正优势比为3.0；95%可信区间为1.4-6.8）在分娩时感染8组链球菌的人数更多。在妊娠小于或等于24周和分娩时，在正常阴道菌群存在的情况下，B组链球菌定植的可能性显着降低。结论：B组链球菌在分娩时定植与早产有关，但在小于或等于妊娠24周时没有定植。
OBJECTIVE: We studied the relationship between group B streptococcal colonization and preterm delivery.STUDY DESIGN: In this prospective study at a single hospital in Odense, Denmark, cervicovaginal cultures were obtained at less than or equal to 24 weeks' gestation from all the women, at delivery from women with preterm deliveries, and from a random sample of women delivering at term.RESULTS: In 2846 singleton births. there was no significant association between group B streptococcal colonization at less than or equal to 24 weeks' gestation and preterm birth. After adjustment for the risk factors for preterm delivery, more women with preterm delivery (12/84, 14%) were colonized at delivery with group 8 streptococci than women with term deliveries (22/300, 7%; adjusted odds ratio, 3.0; 95% confidence interval, 1.4-6.8). Group B streptococcal colonization at less than or equal to 24 weeks' gestation and at delivery was significantly less likely to occur in the presence of normal vaginal flora.CONCLUSION: Group B streptococcal colonization at delivery, but not at less than or equal to 24 weeks' gestation, was associated with preterm delivery.