Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy Cantonese
Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy Cantonese
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首次发现同源重组修复基因的人类遗传变异与健康广东人的EB病毒抗体滴度相关
DOI：
10.1002/ijc.25759
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发表时间：
2011-09-15
影响因子：
6.4
通讯作者：
Jia, Wei-Hua
中科院分区：
文献类型：
--
作者：
Shen, Guo-Ping;Pan, Qing-Hua;Jia, Wei-Hua
eb病毒（EBV）感染是鼻咽癌的主要危险因素。尽管在世界范围内的普通人群中感染流行率很高，但只有一小部分感染者呈现ebv特异性IgA抗体血清阳性。EBV携带者的血清阳性亚组在其一生中患鼻咽癌的累积风险较高。先前的研究报道，宿主同源重组修复（HRR）系统参与EBV裂解复制，提示影响EBV再激活状态从而影响血清阳性的潜在机制。为了研究HRR基因的遗传变异是否与健康人群的血清状态相关，我们对中国南方755名健康广东人进行了一项观察性研究，研究了抗vca - iga血清阳性与35个HRR相关基因的156个标记snp之间的关系。MDC1、RAD54L、TP53BP1、RPA1、LIG3和RFC1 6个变异等位基因与血清阳性相关（p趋势值为0.0085 ~ 0.00027）。我们的研究提供了证据，表明HRR内的遗传变异可能影响个体抗vca IgA抗体EBV血清阳性状态的倾向。
Epstein-Barr virus (EBV) infection is a major risk factor for nasopharyngeal carcinoma (NPC). Despite high prevalence of infection among the general population worldwide, only a small proportion of infected individuals presents with seropositivity for EBV-specific IgA antibodies. This seropositive subgroup of EBV carriers has an elevated cumulative risk for NPC during their lifetime. Previous studies reported that the host homologous recombination repair (HRR) system participates in EBV lytic replication, suggesting a potential mechanism to influence EBV reactivation status and thus seropositivity. To investigate whether genetic variants of HRR genes are associated with the serostatus in a healthy population, we investigated the association between seropositivity for anti-VCA-IgA and 156 tagging SNPs in 35 genes connected with HRR in an observational study among 755 healthy Cantonese speakers in southern China. Six variant alleles of MDC1, RAD54L, TP53BP1, RPA1, LIG3 and RFC1 exhibited associations with seropositivity (p(trend) from 0.0085 to 0.00027). Our study provides evidence that genetic variation within the HRR might affect an individual's propensity for EBV seropositive status of anti-VCA IgA antibody.