Helicobacter pylori risk associated with sibship size and family history of gastric diseases in Japanese adults
Helicobacter pylori risk associated with sibship size and family history of gastric diseases in Japanese adults
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DOI：
10.1111/j.1349-7006.1998.tb00504.x
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发表时间：
1998-11-01
期刊：
影响因子：
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通讯作者：
Sakiyama, T
中科院分区：
文献类型：
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作者：
Kikuchi, S;Kurosawa, M;Sakiyama, T
幽门螺杆菌被认为是胃癌的病因。对日本4,361名公务员进行幽门螺杆菌阳性的危险因素调查，收集血清以及家族史和生活方式信息，并使用血清测定幽门螺杆菌抗体。计算了预计影响幽门螺杆菌血清阳性的因素的性别和年龄调整优势比。将影响显着的因素纳入逻辑回归模型，并通过向后剔除法得到最终模型。同胞人数（4 及以上与 1）、吸烟习惯（当前与从未）以及父亲和兄弟姐妹的胃病史与幽门螺杆菌血清阳性率显着相关，比值比（95% 置信区间）为 1.5 (1.0-2.1)、0.8 (0.7-0.9)、1.5 (1.3-1.8) 和 1.7分别为（1.1-2.6）。然而，配偶的病史并无关联。在最终模型中，同胞大小和父系历史仍然是积极因素，而吸烟则是消极因素。最近研究中关于幽门螺杆菌状态与吸烟之间关系的矛盾结果表明存在隐藏的混杂因素。有人认为，儿童时期家庭成员的感染对日本成年人的幽门螺杆菌状况有很大影响，而成年人之间的感染很少见。
Helicobacter pylori is thought to be a cause of gastric cancer. Risk factors of H. pylori positivity were investigated among 4,361 public service workers in Japan, Sera and information on family history and lifestyle were collected, and H. pylori antibody was measured using the sera. Sex- and age-adjusted odds ratios of factors expected to influence H. pylori seropositivity were calculated. The factors with a significant influence were included in a logistic regression model and the final model was obtained by backward elimination. Sibship size (4 and more vs, 1), smoking habit (current vs. never), and paternal and siblings' histories of gastric diseases showed significant relationships to H, pylori seropositivity, with odds ratios (95% confidence intervals) of 1.5 (1.0-2.1), 0.8 (0.7-0.9), 1.5 (1.3-1.8) and 1.7 (1.1-2.6) respectively. However, spouse's history was not related. In the final model, sibship size and paternal history remained as positive factors, and smoking as a negative one. Contradictory results on the relationship between H. pylori status and smoking among recent studies indicate the existence of hidden confounding factors. It is suggested that infection from family members in childhood considerably affects the H. pylori status of Japanese adults, whereas infection between adults is rare.