Muscle ergoreceptor overactivity reflects deterioration in clinical status and cardiorespiratory reflex control in chronic heart failure
Muscle ergoreceptor overactivity reflects deterioration in clinical status and cardiorespiratory reflex control in chronic heart failure
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DOI：
10.1161/hc4401.098491
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发表时间：
2001-11-06
期刊：
影响因子：
37.8
通讯作者：
Piepoli, MF
中科院分区：
文献类型：
--
作者：
Ponikowski, PP;Chua, TP;Piepoli, MF
Background-In chronic heart failure (CHF), overactivation of ergoreceptors (afferents sensitive to the metabolic effects of muscular work) may be a link between peripheral changes, sympathetic overactivation, and increased hemodynamic and ventilatory responses to exercise. The relationship between ergoreceptors, autonomic changes, and the progression of the syndrome has not yet been studied,Methods and Results-Thirty-eight stable CHF patients (age, 57 +/-1 years; ejection fraction, 26 +/-2%) were compared with 12 age-matched normal control subjects. The ergoreflex contribution to the ventilatory and hemodynannic responses to exercise, together with peripheral and central chemoreceptor sensitivity, arterial baroreflex sensitivity, plasma norepinephrine, epinephrine, and heart rate variability, were measured. Enhanced ergoreflex effects on ventilation (78 +/-2% versus 50 +/-8%), peripheral chemosensitivity (0.6 +/-0.4 versus 0.2 +/-0.1 L/min per percent Sao(2)), and central chemosensitivity (2.9 +/-0.2 versus 2.0 +/-0.2 L . min(-1) . mm Hg-1) and an impaired baroreflex function (4.1 +/-0.6 versus 9.1 +/-5.6 ms/mm Hg) were confirmed in CHF compared with control subjects (P
