GABA(B) receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats.
GABA(B) receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats.
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DOI：
10.1016/j.neurobiolaging.2011.11.011
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发表时间：
2012-06
影响因子：
4.2
通讯作者：
Bizon JL
中科院分区：
文献类型：
--
作者：
McQuail JA;Bañuelos C;LaSarge CL;Nicolle MM;Bizon JL
GABAB 受体 (GABABR) 与广泛的生理和认知过程有关，并且可用于治疗许多神经退行性疾病和精神疾病。由于许多这些疾病都与高龄有关，因此了解正常衰老过程如何影响 GABABR 表达和信号传导非常重要。因此，我们研究了以空间学习任务为特征的年轻和老年大鼠的前额皮质（PFC）和海马中 GABABR 的表达和功能。巴氯芬刺激的 GTP 结合以及 GABABR1 和 GABABR2 蛋白在老年大鼠 PFC 中减少，但这些减少与空间学习能力无关。相比之下，年轻和老年大鼠的海马 GTP 结合程度相当，但在空间学习障碍的老年大鼠中观察到海马 GABABR1 表达减少。这些数据表明，成人和老年人大脑中 GABABR 复合物存在显着的区域差异，可能对理解 GABA 能过程在正常大脑功能中的作用以及针对该系统的假定干预措施的开发产生影响。
GABAB receptors (GABABRs) have been linked to a wide range of physiological and cognitive processes and are of interest for treating a number of neurodegenerative and psychiatric disorders. As many of these diseases are associated with advanced age, it is important to understand how the normal aging process impacts GABABR expression and signaling. Thus, we investigated GABABR expression and function in the prefrontal cortex (PFC) and hippocampus of young and aged rats characterized in a spatial learning task. Baclofen-stimulated GTP-binding and GABABR1 and GABABR2 proteins were reduced in the PFC of aged rats but these reductions were not associated with spatial learning abilities. In contrast, hippocampal GTP-binding was comparable between young and aged rats but reduced hippocampal GABABR1 expression was observed in aged rats with spatial learning impairment. These data demonstrate marked regional differences in GABABR complexes in the adult and aged brain and could have implications for both understanding the role of GABAergic processes in normal brain function and the development of putative interventions that target this system.
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影响因子：
1.9
作者：
GALLAGHER, M;BURWELL, RD;BURCHINAL, M
通讯作者：
BURCHINAL, M
影响因子：
5.8
作者：
Froestl, W;Gallagher, M;Pearlman, R
通讯作者：
Pearlman, R
影响因子：
3.3
作者：
Odagaki, Y;Nishi, N;Koyama, T
通讯作者：
Koyama, T
影响因子：
16.2
作者：
Chalifoux JR;Carter AG
通讯作者：
Carter AG
DOI：
10.1523/jneurosci.2036-08.2008
发表时间：
2008-08-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Boric K;Muñoz P;Gallagher M;Kirkwood A
通讯作者：
Kirkwood A