Prognostic value of serum liver enzymes in oral and oropharynx squamous cell carcinomas
Prognostic value of serum liver enzymes in oral and oropharynx squamous cell carcinomas
复制标题
血清肝酶对口腔和口咽鳞状细胞癌的预后价值
DOI：
10.1111/jop.12803
复制
发表时间：
2019-01-01
影响因子：
3.3
通讯作者：
Song, Xiaomeng
中科院分区：
文献类型：
--
作者：
Zhu, Zaiou;Zhou, Junbo;Song, Xiaomeng
背景
BACKGROUND
Serum liver enzymes, which catalyze relevant catabolic pathways, have been indicated to be diagnostic and prognostic tools for several malignant tumors. The correlation between serum liver enzymes levels and survival in patients with oral and oropharynx squamous cell carcinomas (OSCC) is still absent. Here, we conducted a study focusing on predictive value of serum liver enzymes in terms of prognosis in the patients.
METHODS
A retrospective study including 134 OSCC patients from years 2009 to 2014 was performed to investigate the association between levels of pre-treatment serum liver enzymes, various clinical parameters and prognostic outcomes, which are overall survival (OS) and disease-free survival (DFS). Log-rank tests with Kaplan-Meier method were used to detect potential prognostic biomarkers. Multivariate analyses by Cox proportional hazards model were used to identify significant predictors of prognosis.
RESULTS
Serum adenosine deaminase (ADA) level was associated with patients' OS and DFS by univariate analyses (P = 0.006 and P = 0.024, respectively). Multivariate analyses showed that higher serum ADA (>17.2 U/L) (P = 0.019) as well as positive lymph node status (P = 0.035) independently predicted worse OS of patients with OSCC. In addition, older age (≥60 years) (P = 0.043) and positive lymph node status (P = 0.027) were independently prognostic parameters for poorer DFS.
CONCLUSIONS
Pre-operative serum ADA levels may serve as a reliable independent prognostic predictor for OS in OSCC patients.