Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see).
Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see).
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DOI：
10.1038/nri3667
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Hogquist KA
中科院分区：
文献类型：
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作者：
Klein L;Kyewski B;Allen PM;Hogquist KA
发育中的 T 细胞的命运取决于其抗原受体与胸腺抗原呈递细胞 (APC) 展示的自肽/MHC 复合物的相互作用。各种胸腺 APC 子集战略性地定位在特定的胸腺微环境中，并协调功能性和自我耐受性 T 细胞库的选择。在这里，我们将回顾这些 APC 用于采样和处理自身抗原的不同策略，从而生成部分独特的“特殊”肽/MHC 配体。我们将讨论这些 APC 子集特异性肽/MHC 配体的特殊组成如何不仅塑造胸腺中的 T 细胞库，而且还可能对周围成熟 T 细胞的行为产生不可磨灭的影响。
The fate of developing T cells is specified by interactions of their antigen receptor with self-peptide/MHC complexes displayed by thymic antigen presenting cells (APCs). Various thymic APCs subsets are strategically positioned in particular thymic microenvironments and orchestrate the selection of a functional and self-tolerant T cell repertoire. Here, we will review the different strategies that these APCs employ to sample and process self-antigens and thereby generate partly unique, ‘idiosyncratic’ peptide/MHC ligandomes. We will discuss how the particular composition of these APC-subset-specific peptide/MHC ligandomes not only shapes the T cell repertoire in the thymus, but may also indelibly imprint the behavior of mature T cells in the periphery.