MnSOD genotype and prostate cancer risk as a function of NAT genotype and smoking status.
MnSOD genotype and prostate cancer risk as a function of NAT genotype and smoking status.
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DOI：
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发表时间：
2009
期刊：
影响因子：
2.3
通讯作者：
T. Iguchi;Shozo Sugita;Ching Y. Wang;N. Newman;T. Nakatani;G. Haas
中科院分区：
文献类型：
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作者：
T. Iguchi;Shozo Sugita;Ching Y. Wang;N. Newman;T. Nakatani;G. Haas
背景：香烟烟雾中含有致癌的芳香胺和杂环胺，它们可以通过n -乙酰转移酶（NAT）代谢。这些致癌物还会产生活性氧，由锰超氧化物歧化酶（MnSOD）代谢。研究了前列腺癌（PCA）与MnSOD和NAT多态性及吸烟的关系。患者与方法采用PCR限制性片段长度多态性分析和DNA测序方法，对187例PCA患者和175例年龄匹配的对照者进行MnSOD、NAT1和NAT2基因分型。结果与MnSOD VV和VA相比，MnSOD AA基因型与PCA相关（优势比为1.65；95%可信区间为1.03-2.66）。PCA与NAT或吸烟无关。数据的探索性分析结果表明，PCA和MnSOD的关联仅存在于快速NAT1基因型亚群和吸烟者中。结论本研究证实了PCA与MnSOD的相关性。氧化应激和吸烟可能在具有MnSOD AA和快速NAT1基因型的前列腺癌发生中起重要作用。
BACKGROUND Cigarette smoke contains carcinogenic aromatic and heterocyclic amines that are metabolized by N-acetyltransferase (NAT). These carcinogens also produce reactive oxygen species that are metabolized by manganese superoxide dismutase (MnSOD). The association between prostate cancer (PCA) and the polymorphism of MnSOD and NAT, and cigarette smoking was investigated. PATIENTS AND METHODS DNA samples from 187 PCA patients and 175 age-matched controls were genotyped for MnSOD, NAT1 and NAT2 by PCR restriction fragment length polymorphism analysis and DNA sequencing. RESULTS MnSOD AA genotype, as compared to MnSOD VV and VA, was associated with PCA (odds ratio, 1.65; 95% confidence interval, 1.03-2.66. There was no association of PCA with NAT or smoking. Results of exploratory analyses of the data suggest that the association of PCA and MnSOD exists only in the subpopulation of rapid NAT1 genotypes and smokers. CONCLUSION The present study demonstrates the association of PCA and MnSOD. Oxidative stress and cigarette smoking may play an important role in the carcinogenesis of the prostate in those who have MnSOD AA and rapid NAT1 genotypes.