Physical Activity Monitoring: A Responsive and Meaningful Patient-Centered Outcome for Surgery, Chemotherapy, or Radiotherapy?
Physical Activity Monitoring: A Responsive and Meaningful Patient-Centered Outcome for Surgery, Chemotherapy, or Radiotherapy?
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DOI：
10.1016/j.jpainsymman.2011.06.013
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发表时间：
2012-06-01
影响因子：
4.7
通讯作者：
Fearon, Kenneth C. H.
中科院分区：
文献类型：
--
作者：
Ferriolli, Eduardo;Skipworth, Richard J. E.;Fearon, Kenneth C. H.
上下文。在外科和临床肿瘤学中，越来越需要以患者为中心的结果是有反应的、有意义的和符合目的的。本研究的目的是验证体力活动(PA)监测在疾病和治疗的不同阶段作为一种响应性结果测量的有效性，通过验证体力活动、运动评分和生活质量(QOL)之间的相关性。通过一种记录坐/卧时间、站立时间、步行时间、步行步数和步行节奏的设备，对162名癌症患者的日常生活PA进行了监测，并与20名健康志愿者进行了比较。在一组患者中，使用世界卫生组织/东方合作肿瘤学小组、卡诺夫斯基工作状态评分和欧洲癌症研究与治疗组织生活质量问卷C30(EORTC QLQ-C30)问卷对患者的功能状态和生活质量进行评估。可切除的胃肠道肿瘤患者的PA与对照组相比无显著差异。相比之下，晚期癌症患者的步数减少了45%，每天多躺/坐2.8小时(P=0.001)。接受新辅助化疗和手术的患者(手术后5-6周)的PA也有类似的降低。PA与EORTC QLQ-C30量表中的生理领域、角色领域以及疲劳子维度之间存在显著相关。目的PA评分与癌症患者的疾病分期、功能状态、生活质量密切相关。因此，活动监测可以对患者对癌症及其治疗的反应做出有意义的客观评估，并可能提供替代的生活质量结果。J疼痛症状管理2012；43：1025-1035。(C)2012年美国癌症疼痛缓解委员会。爱思唯尔公司出版，版权所有。
Context. In surgical and clinical oncology, there is a growing need for patient-centered outcomes that are responsive, meaningful, and fit for purpose.Objectives. The aim of this study was to validate physical activity (PA) monitoring as a responsive outcome measure at different stages of disease and treatment, by verifying correlations between PA, performance score, and quality of life (QoL).Methods. Daily life PA of 162 cancer patients, monitored by a device that records time sitting/lying, time standing, time walking, number of steps taken, and walking cadence, was compared with 20 healthy volunteers. In a subgroup of patients, functional status and QoL were assessed using the World Health Organization/Eastern Cooperative Oncology Group and the Karnofsky Performance Status scores and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) questionnaire.Results. The PA of patients with resectable gastrointestinal cancer did not differ significantly from controls. In contrast, patients with advanced cancer took 45% fewer steps and spent an extra 2.8 hours/day lying/sitting (P = 0.001). Patients undergoing neoadjuvant chemotherapy and surgery (5-6 weeks after operation) experienced a similar reduction in PA. There were significant correlations between PA and the physical and role domains as well as fatigue subscale of the EORTC QLQ-C30 scale.Conclusion. Objective PA scores correlate significantly with disease stage, functional status, and QoL of patients with cancer. Therefore, activity monitoring can make meaningful objective estimates of patient function in response to cancer and its treatment and may provide surrogate outcomes of QoL. J Pain Symptom Manage 2012; 43: 1025e1035. (C) 2012 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.