Mismatch negativity in chronic schizophrenia and first-episode schizophrenia
Mismatch negativity in chronic schizophrenia and first-episode schizophrenia
复制标题
DOI：
10.1001/archpsyc.59.8.686
复制
发表时间：
2002-08-01
影响因子：
--
通讯作者：
McCarley, RW
中科院分区：
文献类型：
--
作者：
Salisbury, DF;Shenton, ME;McCarley, RW
背景：失配负性（MMN）是一种与事件相关的大脑电位，对重复模式的刺激偏差很敏感。 MMN被认为主要反映感觉记忆的活动，最多对注意力等高级认知过程有中等影响。据报道，慢性精神分裂症患者的 MMN 降低。然而，尚不清楚首发精神分裂症患者（首次住院时）MMN是否降低。方法：受试者组包括慢性精神分裂症患者（n=16）和老年对照受试者（n=13），以及首发精神分裂症患者（n=21）和年轻对照受试者（n=27）。 MMN 通过从事件相关脑电位到音高偏差音调（1.2 kHz [所有音调的 5%]）减去平均事件相关脑电位到标准音调（1 kHz [所有音调的 95%]）来可视化。 MMN 电压是 100 至 200 毫秒的平均电压。结果：相对于对照组，慢性病患者沿矢状中线的音高偏差 MMN 减少了约 47%。首发精神分裂症患者的 MMN 并未降低。与左半球相比，所有 4 组患者的右半球的音调偏差 MMN 大约增加了 64%。结论：慢性精神分裂症患者在首次住院时并不存在音调偏差 MMN 的减少。在精神分裂症疾病过程的早期，由 MMN 索引的感觉、回声记忆功能似乎不受影响。 MMN 振幅可能会随着时间的推移而降低，并指示疾病的进展，尽管这只能通过纵向评估来明确确定。
Background: Mismatch negativity (MMN) is an event-related brain potential that is sensitive to stimulus deviation from a repetitive pattern. The MMN is thought primarily to reflect the activity of sensory memory, with, at most, moderate influences of higher-level cognitive processes, such as attention. The MMN is reported to be reduced in patients with chronic schizophrenia. However, it is unknown whether MMN is reduced in patients with first-episode schizophrenia (at first hospitalization).Methods: Subject groups comprised patients with chronic schizophrenia (n=16) and older control subjects (n=13), and patients with first-episode schizophrenia (n=21) and younger control subjects (n=27). The MMN was visualized by subtracting the averaged event-related brain potential to standard tones (1 kHz [95% of all tones]) from the event-related brain potential to pitch-deviant tones (1.2 kHz [5% of all tones]). The MMN voltage was the mean voltage from 100 to 200 milliseconds.Results: Pitch-deviant MMN was reduced by approximately 47% in patients with chronic illness along the sagittal midline relative to controls. The MMN was not reduced in patients with first-episode schizophrenia. All 4 groups showed approximately 64% larger MMN to pitch-deviant tones over the right hemisphere compared with the left hemisphere.Conclusions: The pitch-deviant MMN reductions present in patients with chronic schizophrenia are not present at first hospitalization. The sensory, echoic memory functions indexed by MMN seem unaffected early in the schizophrenia disease process. Reductions in MMN amplitude may develop over time and index the progression of the disorder, although that can only be definitively determined by longitudinal assessments.