Cathepsin K in Lymphangioleiomyomatosis LAM Cell-Fibroblast Interactions Enhance Protease Activity by Extracellular Acidification
Cathepsin K in Lymphangioleiomyomatosis LAM Cell-Fibroblast Interactions Enhance Protease Activity by Extracellular Acidification
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DOI：
10.1016/j.ajpath.2017.04.014
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发表时间：
2017-08-01
影响因子：
6
通讯作者：
Johnson, Simon R.
中科院分区：
文献类型：
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作者：
Dongre, Arundhati;Clements, Debbie;Johnson, Simon R.
淋巴管平滑肌瘤病 (LAM) 是一种罕见疾病，其中 LAM 细胞和成纤维细胞形成肺结节，据推测，LAM 结节衍生的蛋白酶会导致囊肿形成和组织损伤。在整个肺组织中的蛋白酶基因表达谱中，与对照肺组织相比，LAM 中的组织蛋白酶 K 基因表达过表达 40 倍（P
Lymphangioleiomyomatosis (LAM) is a rare disease in which LAM cells and fibroblasts form Lung nodules and it is hypothesized that LAM nodule-derived proteases cause cyst formation and tissue damage. On protease gene expression profiling in whole lung tissue, cathepsin K gene expression was 40-fold overexpressed in LAM compared with control Lung tissue (P