Novel roles of plant RETINOBLASTOMA-RELATED (RBR) protein in cell proliferation and asymmetric cell division.
Novel roles of plant RETINOBLASTOMA-RELATED (RBR) protein in cell proliferation and asymmetric cell division.
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DOI：
10.1093/jxb/ert411
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发表时间：
2014-06
影响因子：
6.9
通讯作者：
Gutierrez C
中科院分区：
文献类型：
--
作者：
Desvoyes B;de Mendoza A;Ruiz-Trillo I;Gutierrez C
视网膜母细胞瘤 (Rb) 蛋白被鉴定为人类肿瘤抑制蛋白，通过与 E2F 转录因子家族成员的相互作用来控制细胞增殖的各个阶段。它最初被认为是动物特有的，但植物中含有 Rb 的同系物，称为视网膜母细胞瘤相关 (RBR)。事实上，Rb-E2F模块似乎是真核生物非常早期获得的。 RBR 的活性取决于某些氨基酸残基的磷酸化，这些残基在大多数情况下在植物和动物蛋白质之间非常保守。除了在细胞周期进展中的作用外，RBR 还被证明参与各种细胞过程，如内复制、转录调节、染色质重塑、细胞生长、干细胞生物学和分化。在这里，我们讨论定义 RBR 在细胞增殖和不对称细胞分裂中的作用的最新进展。这些和其他报告明确支持这样的观点：RBR 被用作大量细胞蛋白质和复合物的着陆平台，以控制细胞生理学和植物发育的各个方面。
The retinoblastoma (Rb) protein was identified as a human tumour suppressor protein that controls various stages of cell proliferation through the interaction with members of the E2F family of transcription factors. It was originally thought to be specific to animals but plants contain homologues of Rb, called RETINOBLASTOMA-RELATED (RBR). In fact, the Rb–E2F module seems to be a very early acquisition of eukaryotes. The activity of RBR depends on phosphorylation of certain amino acid residues, which in most cases are well conserved between plant and animal proteins. In addition to its role in cell-cycle progression, RBR has been shown to participate in various cellular processes such as endoreplication, transcriptional regulation, chromatin remodelling, cell growth, stem cell biology, and differentiation. Here, we discuss the most recent advances to define the role of RBR in cell proliferation and asymmetric cell division. These and other reports clearly support the idea that RBR is used as a landing platform of a plethora of cellular proteins and complexes to control various aspects of cell physiology and plant development.