Functional plasticity in memory T helper cell responses
Functional plasticity in memory T helper cell responses
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DOI：
10.4049/jimmunol.178.7.4080
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发表时间：
2007-04-01
影响因子：
4.4
通讯作者：
Pearce, Edward J.
中科院分区：
文献类型：
--
作者：
Krawczyk, Connie M.;Shen, Hao;Pearce, Edward J.
激活后，初始CD4(+) Th细胞可以分化为选择性地产生Th1谱系特异性细胞因子ifn - γ或Th2细胞因子IL-4，并在此过程中失去产生替代谱系细胞因子的能力。小鼠CD4(+) T细胞的谱系承诺在很大程度上被认为是绝对的，在产生相反谱系的细胞因子方面几乎没有灵活性。在这项研究中，我们证明了Th2记忆群体中的细胞如果在有利于Th1细胞发育的先天反应的背景下在体内被重新激活，可以产生ifn - γ。同样，Thl记忆群体中的细胞在促进Th2反应的条件下受到挑战时产生IL-4。效应细胞和未极化的中枢记忆细胞都保留了产生细胞因子的潜力，这些细胞因子在初次反应中是不产生的。这些发现表明，效应和中枢记忆Th1和Th2细胞都具有响应环境线索产生相反谱系的病原体适当细胞因子的能力。
Following activation, naive CD4(+) Th cells can differentiate to selectively produce either the Th1 lineage-specific cytokine IFN-gamma or the Th2 cytokine IL-4 and, in so doing, lose the capacity to produce cytokines of the alternative lineage. Lineage commitment of murine CD4(+) T cells has largely been considered to be absolute with little flexibility to produce cytokines of the opposing lineage. In this study, we demonstrate that cells within Th2 memory populations can produce IFN-gamma if reactivated in vivo in the context of an innate response that favors Th1 cell development. Likewise, cells within Thl memory populations produce IL-4 when challenged under conditions that promote Th2 responses. Both effector and unpolarized central memory cells retain the potential to produce cytokines that were not made during the primary response. These findings reveal that both effector and central memory Th1 and Th2 cells possess the capacity to respond to environmental cues to produce pathogen-appropriate cytokines of the opposing lineage.