The microRNA.org resource: targets and expression.

The microRNA.org resource: targets and expression.
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DOI:
10.1093/nar/gkm995
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发表时间:
2008-01
影响因子:
14.9
通讯作者:
Sander C
Sander C
中科院分区:
生物学2区
文献类型:
--
作者:
Betel D;Wilson M;Gabow A;Marks DS;Sander C

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MicroRNA.org(http://www.microrna.org)是一个有关微小RNA(microRNA)靶标预测和表达谱的综合资源库。靶标预测基于对miRanda算法的改进,该算法融合了有关靶标规则的现有生物学知识以及对最新的哺乳动物微小RNA概要的使用。微小RNA表达谱来自对大量正常和疾病来源的哺乳动物组织及细胞系的综合测序项目。通过使用改进的图形界面,用户可以探索(i)可能受特定微小RNA调控的一组基因,(ii)多个微小RNA在特定信使RNA(mRNA)上的隐含协同作用,以及(iii)微小RNA在各种组织中的表达谱。为了便于未来的更新和发展,microRNA.org数据库结构和软件架构被灵活设计,以纳入新的表达和靶标发现。该网络资源为用户提供了有关越来越多的微小RNA及其在许多物种中与靶标基因相互作用的功能信息,并促进了在微小RNA基因调控方面的新发现。
MicroRNA.org (http://www.microrna.org) is a comprehensive resource of microRNA target predictions and expression profiles. Target predictions are based on a development of the miRanda algorithm which incorporates current biological knowledge on target rules and on the use of an up-to-date compendium of mammalian microRNAs. MicroRNA expression profiles are derived from a comprehensive sequencing project of a large set of mammalian tissues and cell lines of normal and disease origin. Using an improved graphical interface, a user can explore (i) the set of genes that are potentially regulated by a particular microRNA, (ii) the implied cooperativity of multiple microRNAs on a particular mRNA and (iii) microRNA expression profiles in various tissues. To facilitate future updates and development, the microRNA.org database structure and software architecture is flexibly designed to incorporate new expression and target discoveries. The web resource provides users with functional information about the growing number of microRNAs and their interaction with target genes in many species and facilitates novel discoveries in microRNA gene regulation.
miRNAMAP:哺乳动物基因组中microRNA基因及其靶基因的基因组图。
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