Therapeutic Uses and Pharmacological Properties of Garlic, Shallot, and Their Biologically Active Compounds
Therapeutic Uses and Pharmacological Properties of Garlic, Shallot, and Their Biologically Active Compounds
复制标题
DOI：
10.22038/ijbms.2013.1865
复制
发表时间：
2013-10
影响因子：
2.2
通讯作者：
P. Mikaili;Surush Maadirad;Milad Moloudizargari;S. Aghajanshakeri;Shadi Sarahroodi
中科院分区：
文献类型：
--
作者：
P. Mikaili;Surush Maadirad;Milad Moloudizargari;S. Aghajanshakeri;Shadi Sarahroodi
目的：大蒜（Allium sativum L.）百合科）在伊朗是众所周知的，它的叶子、花和丁香已经在传统医学中使用了很长时间。近几十年来的研究表明，黄芪具有广泛的药理作用。大蒜及其有机硫化合物，特别是大蒜素。对该植物的化学成分进行的研究表明，该植物最重要的成分是有机硫化合物，如大蒜素、二烯丙基二硫化物、S-烯丙基半胱氨酸和二烯丙基三硫化物。大蒜素是这些天然化合物中研究最多的一种。除A. sativum，这些化合物也存在于A. Hirtifolium（葱），并已用于治疗各种疾病。本文综述了黄芪的药理作用和传统用途。sativum，A.硬叶植物及其活性成分，以表明它们是否可以进一步用作新药开发的潜在天然来源。材料和方法：为此，作者查阅了大量的资料和文献，收集了所有需要的数据。对调查结果进行了审查，并根据与专题的相关性进行了分类，并以表格形式报告了所有影响的摘要。结论：大蒜和青葱是安全、低毒的生物活性物质的丰富来源。需要进一步的研究来确认临床医生用作治疗剂的植物的安全性和质量。
Objective(s): Garlic (Allium sativum L. family Liliaceae) is well known in Iran and its leaves, flowers, and cloves have been used in traditional medicine for a long time. Research in recent decades has shown widespread pharmacological effects of A. sativum and its organosulfur compounds especially Allicin. Studies carried out on the chemical composition of the plant show that the most important constituents of this plant are organosulfur compounds such as allicin, diallyl disulphide, S-allylcysteine, and diallyl trisulfide. Allicin represents one of the most studied among these naturally occurring compounds. In addition to A. sativum, these compounds are also present in A. hirtifolium (shallot) and have been used to treat various diseases. This article reviews the pharmacological effects and traditional uses of A. sativum, A. hirtifolium, and their active constituents to show whether or not they can be further used as potential natural sources for the development of novel drugs. Materials and Methods: For this purpose, the authors went through a vast number of sources and articles and all needed data was gathered. The findings were reviewed and classified on the basis of relevance to the topic and a summary of all effects were reported as tables. Conclusion: Garlic and shallots are safe and rich sources of biologically active compounds with low toxicity. Further studies are needed to confirm the safety and quality of the plants to be used by clinicians as therapeutic agents.