Erythropoietin and Neonatal Neuroprotection.
Erythropoietin and Neonatal Neuroprotection.
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DOI：
10.1016/j.clp.2015.04.004
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发表时间：
2015-09
影响因子：
2.1
通讯作者：
Pet GC
中科院分区：
文献类型：
--
作者：
Juul SE;Pet GC
某些新生儿群体有发生长期神经发育障碍（NDI）的高风险，可能被认为是神经保护干预的候选人。本章将探讨其中一些高危人群，脑损伤的相关机制，以及细胞损伤和死亡的具体机制。促红细胞生成素（Epo）作为新生儿脑损伤的神经保护剂的潜力将进行讨论。更新了Epo神经保护在早产儿和足月儿中的临床试验。
Certain groups of neonates are at high risk of developing long-term neurodevelopmental impairment (NDI) and might be considered candidates for neuroprotective interventions. This chapter will explore some of these high-risk groups, relevant mechanisms of brain injury, and specific mechanisms of cellular injury and death. The potential of erythropoietin (Epo) to act as a neuroprotective agent for neonatal brain injury will be discussed. Clinical trials of Epo neuroprotection in preterm and term infants are updated.