Multifunctional Bi2WO6 Nanoparticles for CT-Guided Photothermal and Oxygen-free Photodynamic Therapy
Multifunctional Bi2WO6 Nanoparticles for CT-Guided Photothermal and Oxygen-free Photodynamic Therapy
复制标题
用于 CT 引导光热和无氧光动力治疗的多功能 Bi2WO6 纳米粒子
DOI：
10.1021/acsami.7b16000
复制
发表时间：
2018-01-10
影响因子：
9.5
通讯作者：
Hu, Yong
中科院分区：
文献类型：
--
作者：
Zhang, Chao;Ren, Jing;Hu, Yong
光动力疗法（PDT）对氧气的消耗显著加剧了肿瘤组织的缺氧程度，不仅阻碍了PDT的治疗效果，而且还促使肿瘤局部复发。为了缓解PDT引起的缺氧并改善PDT在癌症治疗中的治疗效果，本文报道了一类Bi2WO6纳米颗粒（NPs）作为一种强大的多功能平台，其以无氧方式集成了对比增强计算机断层扫描（CT）成像、光热治疗和PDT的能力。所获得的Bi2WO6纳米颗粒的平均直径为5.2 nm是稳定的磷酸盐缓冲盐水和体内微环境模拟缓冲液。Bi_2WO_6增强CT具有较高的空间分辨率，可准确定位实体瘤的位置。在808 nm激光照射下，这些Bi2WO6纳米粒子可以实现CT引导下的肿瘤局部光热消融。同时，在治疗过程中同时产生 *OH自由基，而不消耗氧分子，这使得这些Bi2WO6 NP能够在癌症治疗期间以无氧方式发挥光动力学杀伤作用。在携带HeLa异种移植物的小鼠中观察到显着的肿瘤抑制，支持这些多功能Bi2WO6 NPs通过协同光热和无氧PDT治疗在对抗癌症中的有希望的应用。
The consumption of oxygen in photodynamic therapy (PDT) significantly exacerbates the degree of hypoxia in tumors, which not only impedes the therapeutic effect of PDT, but also drives local tumor recurrence. To relieve the PDT-induced hypoxia and improve the therapeutic outcome of PDT in cancer treatment, herein we reported a class of Bi2WO6 nanoparticles (NPs) as a robust multifunctional platform, which integrates the abilities for contrast-enhanced computed tomography (CT) imaging, photothermal therapy, and PDT in an oxygen-free manner. The as-obtained Bi2WO6 NPs with a mean diameter of 5.2 nm are stable in phosphate-buffered saline and an in vivo microenvironment-mimicking buffer. The location of the solid tumor could be accurately positioned using Bi2WO6-enhanced CT with higher spatial resolution. After being irradiated with an 808 nm laser, these Bi2WO6 NPs could realize CT-guided local photothermal ablation of the tumor. Meanwhile, *OH radicals were generated simultaneously from the treatment without consuming an oxygen molecule, which enabled these Bi2WO6 NPs to exert photodynamic killing effect in an oxygen-free manner during cancer therapy. Remarkable tumor suppression was observed in mice bearing the HeLa xenograft, supporting the promising application of these multifunctional Bi2WO6 NPs in the combat against cancers through synergistic photothermal and oxygen-free PDT treatment.