Biochemical diagnosis of alcoholism
Biochemical diagnosis of alcoholism
复制标题
DOI：
10.1007/bf02893039
复制
发表时间：
2008
影响因子：
2.1
通讯作者：
S. Das;D. Vasudevan
中科院分区：
文献类型：
--
作者：
S. Das;D. Vasudevan
医学上诊断的酗酒者可以通过临床实验室检查可靠地与非酗酒者区分开来。本研究将酒精所致肝病患者与非酒精所致肝病患者与一组正常健康人进行比较。与其他组相比，重度饮酒者的体重和体脂率明显较低，身体质量指数也较低。酒精性肝病（ALD）的血红蛋白百分比和红细胞总数显著降低，而平均红细胞体积（MCV）显著升高。高胆红素血症、高尿酸血症和低白蛋白血症与饮酒有关。ALD患者白蛋白/球蛋白比值显著降低。急性肝损伤时AST/ALT比值≤1.0，而酒精性肝炎时AST/ALT比值为bbb1.0。中度升高的ALP和高GGT值是酒精患者的良好鉴别指标。酒精性肝损伤与氧化应激有关，可通过还原性谷胱甘肽和抗坏血酸水平降低，以及硫代巴比妥酸反应性物质水平升高观察到。
Medically diagnosed alcoholics can be differentiated reliably from non-alcoholics using clinically laboratory tests. In the present study, patients with liver diseases either due to alcohol or without alcohol compared with a group of normal healthy persons. Heavy drinkers showed significantly lower body weight and percent body fat, and low BMI compared with other groups. The percentage of hemoglobin and total number of RBC were found to be significantly decreased, whereas mean corpuscular volume (MCV) significantly increased in alcoholic liver disease (ALD). Hyperbilirubinemia, hyperuricemia and hypoalbuminemia correlate with alcohol intake. Albumin/globulin ratio significantly decreased in ALD. In acute liver injury AST/ALT ratio is ≤1.0, whereas in alcoholic hepatitis it is always >1.0. Moderately elevated level of ALP and high GGT values are good discriminator of alcoholic patients. Alcohol-induced liver injury is linked to oxidative stress as observed by decreased level of reduced glutathione and ascorbic acid, and increased level of thiobarbituric acid reactive substances.