Brain stem modulation of spatial receptive field properties of single cells in the dorsal lateral geniculate nucleus of the cat.
Brain stem modulation of spatial receptive field properties of single cells in the dorsal lateral geniculate nucleus of the cat.
复制标题
猫背外侧膝状核中单细胞空间感受野特性的脑干调节。
DOI：
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发表时间：
1993
影响因子：
2.5
通讯作者：
P. Heggelund
中科院分区：
文献类型：
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作者：
E. Hartveit;S. Ramberg;P. Heggelund
1. 我们研究了脑干臂周区（PBR）的电刺激对背外侧膝状核（dLGN）单细胞对在接受野的一系列位置上出现的光狭缝的视觉反应的影响。根据狭缝位置绘制响应图，给出空间感受野剖面。2. PBR刺激显著增加视觉反应。在感受野中心的中部，绝对反应的增加明显大于周围的感受野部分或自发活动的增加。PBR刺激也导致感受野中心直径的小幅增加。3. PBR刺激后，dLGN细胞感受野轮廓的最大陡峭度增加。我们认为，dLGN细胞的视觉分辨率与感受野轮廓的最大斜率直接相关，而不是与感受野中心的宽度相关。这意味着PBR输入的增加，正如在觉醒期间可能发生的那样，增加了dLGN细胞的视觉分辨率。4. 对于一些细胞，除了动作电位外，我们还可以记录到s电位（慢电位）。这使我们能够直接比较dLGN细胞的感受野中心大小与其视网膜输入的大小。对于这些细胞，中心的大小被膝状接力大大减小。在PBR刺激期间，这些细胞的中心大小也略有增加，但即使在这种情况下，与视网膜输入相比，它也减小了。PBR刺激时dLGN细胞感受野剖面的最大斜率大于视网膜输入。5. 我们还研究了离子电泳应用乙酰胆碱（ACh）和甲基二库兰（BMC）对dLGN细胞空间感受野特性的影响。乙酰胆碱的作用与PBR刺激相似。另一方面，BMC的应用使感受野轮廓与视网膜神经节细胞更相似。
1. We studied the effect of electrical stimulation of the peribrachial region (PBR) in the brain stem on the visual response of single cells in the dorsal lateral geniculate nucleus (dLGN) to a light slit presented in a series of positions across the receptive field. The response was plotted against slit position, giving a spatial receptive field profile. 2. PBR stimulation markedly increased the visual response. In the middle of the receptive field center, the absolute response increase was considerably larger than in the peripheral parts of the receptive field or than the increase of spontaneous activity. The PBR stimulation also led to a small increase of the diameter of the receptive field center. 3. The maximum steepness of the receptive field profile for the dLGN cells increased by PBR stimulation. We suggest that the visual resolution in the dLGN cell is directly related to this maximal slope of the receptive field profile rather than to the width of the receptive field center. This would mean that increased input from the PBR, as presumably occurs during arousal, increases the visual resolution of the dLGN cells. 4. For some of the cells we could record S-potentials (slow potentials) in addition to action potentials. This allowed us to directly compared the receptive field center size of a dLGN cell with that of its retinal input. For these cells, the center size was considerably reduced by the geniculate relay. During PBR stimulation, the center size of these cells also increased slightly, but even in this condition it was reduced compared with the retinal input. The maximal slope of the receptive field profile in the dLGN cell during PBR stimulation was larger than for the retinal input. 5. We also examined the effect of ionophoretical application of acetylcholine (ACh) and bicuculline methchloride (BMC) on the spatial receptive field properties of dLGN cells. The effects of ACh were similar to those of PBR stimulation. Application of BMC, on the other hand, made the receptive field profile more similar to that of retinal ganglion cells.