Clinical relevance of viral dynamics and genotypes in hepatitis B virus.
Clinical relevance of viral dynamics and genotypes in hepatitis B virus.
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DOI：
10.1046/j.1440-1746.17.s3.21.x
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发表时间：
2002-12-01
影响因子：
4.1
通讯作者：
Locarnini, Stephen A
中科院分区：
文献类型：
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作者：
Locarnini, Stephen A
分子诊断技术的进步使得精确测量病毒载量成为可能，这使得对HIV、丙型肝炎病毒（HCV）和B肝炎病毒（HBV）的病毒动力学进行详细研究成为可能。抗病毒治疗后，病毒载量衰减至少有两个阶段：一个对应于游离病毒体的清除，第二个较慢的阶段对应于感染细胞的根除。数学模型的应用允许评估抗病毒疗效和改进治疗方案的设计。这些工具的临床应用应有助于优化患者结果。分子诊断的另一个优点是在选择性压力情况下表征特定患者群体中病毒的异质性。HBV可分为主要具有地理分布的七种主要基因型（A-G）。最近的基因型研究揭示了HBV感染中病毒基因分型的临床和治疗相关性。
Advances in molecular diagnostic technology make it possible to accurately measure viral loads and this has allowed the detailed study of viral dynamics of HIV, hepatitis C virus (HCV) and hepatitis B virus (HBV). Following antiviral therapy, there are at least two phases of viral load decay: one corresponding to clearance of free virions and a second, slower phase corresponding to eradication of infected cells. Application of mathematical models allows for the assessment of antiviral efficacy and improved design of therapeutic regimens. The clinical application of these tools should help optimize patient outcome. Another advantage of molecular diagnostics is characterization of the heterogeneity of viruses in particular patient populations under selective pressure situations. The HBV can be classified into seven major genotypes (A-G) that have mainly a geographic distribution. Recent genotypic studies have revealed the clinical and therapeutic relevance of viral genotyping in HBV infections.