MUSCLE-FIBER TYPE AND DIMENSION IN GENETICALLY-OBESE AND LEAN ZUCKER RATS
MUSCLE-FIBER TYPE AND DIMENSION IN GENETICALLY-OBESE AND LEAN ZUCKER RATS
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DOI：
10.1111/j.1748-1716.1995.tb09938.x
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发表时间：
1995-09-01
期刊：
影响因子：
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通讯作者：
MEDBO, JI
中科院分区：
文献类型：
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作者：
HE, D;BOLSTAD, G;MEDBO, JI
骨骼肌结构和形态可能会改变肥胖。为了进一步研究这一点，在15周龄时检查了6只遗传性肥胖（fa/fa）和6只正常雄性大鼠的肌肉。解剖出臀中肌、股外侧肌和腹直肌，染色进行纤维组织化学分型。此外，在图形板上测量纤维横截面积。肥胖大鼠股外侧肌和腹直肌的快缩纤维比例较大（P < 0.01），臀中肌的快缩纤维比例无明显差异。正常大鼠的快缩肌纤维的横截面积比同块肌肉的慢缩肌纤维的横截面积大2-3倍。肥胖大鼠快缩肌纤维的横截面积比对照组小40-47%（P < 0.003），而慢缩肌纤维的横截面积两组间无差异。因此，这些数据表明，在遗传性肥胖的大鼠中，快速收缩纤维的发育主要受到影响。此外，在这些动物中，某些肌肉可能比其他肌肉受到的影响更大。
Skeletal muscle structure and morphology may be altered in obesity. To study this further, muscles from six genetically obese (fa/fa) and six normal male rats were examined at 15 weeks of age. The gluteus medius, vastus lateralis and rectus abdominis muscles were dissected out and stained for histochemical fibre typing. In addition the fibre cross-sectional area was measured on a graphic tablet. The proportion of fast-twitch fibres was larger in the vastus lateralis and rectus abdominis muscles of the obese rats (P < 0.01); no difference was seen for the gluteus medius muscle. For the normal rats the cross-sectional area of the fast-twitch fibres was 2-3 times larger than the area of slow-twitch fibres in the same muscle. The cross-sectional area of the fast-twitch fibres in the obese rats was 40-47% less than in the control animals (P < 0.003), while no difference between the two groups was found for the slow-twitch fibre area. The data thus suggest that in the genetically obese rats the development of fast-twitch fibres was primarily affected. Moreover, in these animals some muscles may be more affected than others.