Air oxidation increases skin irritation from fragrance terpenes
Air oxidation increases skin irritation from fragrance terpenes
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DOI：
10.1111/j.1600-0536.2008.01471.x
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发表时间：
2009-01-01
影响因子：
5.5
通讯作者：
Matura, Mihaly
中科院分区：
文献类型：
--
作者：
Christensson, Johanna Brared;Forsstrom, Pia;Matura, Mihaly
背景：芳樟醇和柠檬烯是常见的芳香萜烯，在空气中暴露时会自动氧化。纯化合物不会引起过敏，但其氧化产物可引起接触性过敏。关于氧化萜烯的刺激性研究很少目的：本研究的目的是研究浓度系列中纯的和氧化的R-柠檬烯和芳樟醇的刺激性作用，并研究MNIC（最大非刺激性浓度）的自氧化芳樟醇和柠檬烯。患者/方法：在皮炎患者和对照组中用氧化和非氧化芳樟醇的顺序稀释浓度进行斑贴试验，以及氧化的和非氧化的R-柠檬烯。读数进行了视觉评估，并使用激光多普勒imaging.Results：非氧化萜烯在所有测试浓度无刺激性。芳樟醇，特别是R-柠檬烯氧化后，与纯化合物相比，更刺激。皮炎患者和controls.Conclusion：芳香萜烯芳樟醇和R-柠檬烯的自氧化增加刺激性之间的反应没有差异。氧化芳樟醇的刺激性小于氧化R-柠檬烯。在这项研究中，我们发现使用激光多普勒技术相比，视觉评估没有优势。
Background: Linalool and limonene are common fragrance terpenes that autoxidize on air exposure. The pure compounds are not allergenic but their oxidation products can cause contact allergy. Little has been investigated regarding the irritancy of oxidized terpenes.Aim: The aim of this study was to investigate the irritating effect of pure and oxidized R-limonene and linalool in concentration series and to study the MNIC (Maximum Non Irritant Concentration) of autoxidized linalool and limonene.Patients/methods: Patch testing was performed in dermatitis patients and controls with sequentially diluted concentrations of oxidized and non-oxidized linalool, and oxidized and non-oxidized R-limonene. Readings were made with visual assessment and using laser Doppler imaging.Results: The non-oxidized terpenes were non-irritating in all tested concentrations. Both linalool and especially R-limonene were more irritating after oxidation compared with the pure compounds. No difference in response was seen between dermatitis patients and controls.Conclusion: Autoxidation of the fragrance terpenes linalool and R-limonene increases irritation. Oxidized linalool is less irritating than oxidized R-limonene. In this study, we found no advantages in using laser Doppler technique compared with visual assessment.